In the meticulous world of analytical chemistry, the choice of solvent can dramatically influence the accuracy and efficiency of experiments. 1-Chlorobutane (n-Butyl Chloride) has emerged as a valuable solvent, particularly in techniques like High-Performance Liquid Chromatography (HPLC) and spectrophotometry, owing to its distinct physical and chemical properties. As a dedicated supplier of fine chemicals, we understand the critical needs of laboratory professionals and offer high-grade 1-Chlorobutane to meet these demands.

Understanding the Solvent Properties of 1-Chlorobutane:

1-Chlorobutane (CAS: 109-69-3) is a colorless, volatile liquid characterized by its pungent odor and excellent solvency for a range of organic compounds, including waxes, fats, and oils. Its key attributes that make it suitable for analytical applications include:

  • Good Solvency: It effectively dissolves many organic analytes, facilitating their introduction into analytical systems.
  • Appropriate Polarity: While not highly polar, its polarity is suitable for extracting and analyzing specific organic compounds, especially in contrast to aqueous phases.
  • Low Non-Volatile Residue: For techniques like HPLC and spectrophotometry, a solvent with minimal non-volatile residue is crucial to prevent contamination of sensitive equipment and ensure clear spectra. High-purity grades of 1-Chlorobutane are manufactured to meet these low residue requirements.
  • UV Transparency: In spectrophotometry, the solvent should not absorb significantly in the wavelength range of interest. Specific grades of 1-Chlorobutane are tested for their UV transmittance.

Applications in Analytical Techniques:

Laboratory professionals utilize 1-Chlorobutane in several analytical contexts:

  • High-Performance Liquid Chromatography (HPLC): As a mobile phase component or in sample preparation, 1-Chlorobutane can be used for the separation and analysis of various organic molecules. Its solvency and compatibility with certain stationary phases make it a practical choice for specific chromatographic methods.
  • Spectrophotometry: It serves as a suitable solvent for analyzing compounds that are soluble in it and do not interfere with the spectroscopic analysis.
  • Environmental Testing: Its ability to extract organic contaminants from environmental samples makes it useful in sample preparation for analytical testing of soil, water, or air samples.
  • Forensic Toxicology: 1-Chlorobutane is often employed as an extraction solvent in forensic toxicology due to its ability to separate organic compounds from aqueous samples. Its density, being lower than water, allows it to settle above the aqueous layer, simplifying sample separation.

Choosing the Right Grade:

When purchasing 1-Chlorobutane for laboratory use, especially for critical analytical applications, it is imperative to buy from reputable manufacturers that provide specific grades like 'HPLC grade' or 'spectrophotometry grade'. These grades ensure the absence of impurities that could interfere with measurements, providing reliable and reproducible results. Always consult the product specifications and SDS before use.

For laboratories requiring high-quality solvents for their analytical needs, sourcing 1-Chlorobutane from a trusted chemical manufacturer and supplier is key to achieving accurate and efficient results.