In the intricate world of chemical manufacturing and research, understanding the properties and applications of key intermediates is fundamental. 1,2,5,8-Tetrahydroxyanthraquinone (CAS 81-61-8), also known as Quinalizarin, is a significant organic compound that finds utility in various sectors, particularly in organic synthesis and as a precursor for Active Pharmaceutical Ingredients (APIs). This guide provides a detailed look at its characteristics and offers insights for businesses seeking to buy this essential fine chemical.

Chemical Profile and Properties

1,2,5,8-Tetrahydroxyanthraquinone, with the chemical formula C14H8O6, is a derivative of anthraquinone featuring four hydroxyl groups strategically placed on its aromatic rings. Its typical appearance is a white or off-white powder. Key physical and chemical properties include:

  • Molecular Weight: 272.21 g/mol
  • Melting Point: Approximately 99°C (though some sources list decomposition above 300°C), indicating it is a solid at room temperature.
  • Purity: Commonly available in purities of 95% and 98%, with higher purity grades being essential for demanding synthesis applications and API intermediate roles.
  • Solubility: Generally soluble in organic solvents, typical for many organic dyes and intermediates.

Applications in Chemistry and Pharmaceuticals

The versatile structure of 1,2,5,8-Tetrahydroxyanthraquinone lends itself to several important applications:

  • Organic Synthesis Intermediate: It serves as a valuable building block in complex organic synthesis. The reactive hydroxyl groups and the stable anthraquinone core allow for a range of chemical transformations, enabling the creation of diverse molecular structures.
  • API Intermediate: Its utility extends to the pharmaceutical industry, where it can function as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Researchers and manufacturers looking for reliable precursors for drug synthesis often consider this compound.
  • Dye and Pigment Applications: Historically, anthraquinone derivatives have been used as dyes. While its primary modern use is in synthesis, its inherent color properties suggest potential in specialized dye or pigment formulations.
  • Research and Development: As a well-characterized organic compound, it is frequently used in academic and industrial R&D settings to explore new synthetic methodologies and potential applications in materials science and medicinal chemistry.

Sourcing 1,2,5,8-Tetrahydroxyanthraquinone: A Buyer's Guide

For businesses that need to buy 1,2,5,8-Tetrahydroxyanthraquinone, a strategic approach to sourcing is vital. Manufacturers in China are a significant source for this fine chemical, offering competitive pricing and high-volume production capabilities. When engaging with a supplier for CAS 81-61-8:

  • Verify Purity: Always confirm the purity level (e.g., 98%) meets your application's requirements.
  • Assess Supplier Reliability: Look for suppliers with strong quality control systems and a proven track record in chemical manufacturing. Request Certificates of Analysis (CoA).
  • Compare Quotes: Obtain detailed quotations from multiple manufacturers, considering factors like Incoterms, payment terms, and lead times.
  • Understand Packaging: Confirm that packaging meets necessary safety and transportation standards for chemical intermediates.

By focusing on these aspects, procurement managers and R&D scientists can ensure they acquire a high-quality, reliable supply of 1,2,5,8-Tetrahydroxyanthraquinone, supporting the efficient progression of their organic synthesis and pharmaceutical development projects.