4-Bromo-2-fluorobenzoyl Chloride: A Key Building Block for Chemical Innovation
In the intricate world of chemical synthesis, specialized building blocks are indispensable for crafting complex molecules. 4-Bromo-2-fluorobenzoyl Chloride, identified by its CAS number 151982-51-3, is a prime example of such a crucial intermediate. Its unique combination of a benzoyl chloride core with bromine and fluorine substituents makes it a highly sought-after compound for a variety of chemical applications. This article explores its fundamental properties, synthesis methods, and the broad spectrum of its uses, highlighting its significance as a key component in chemical innovation.
The molecular structure of 4-Bromo-2-fluorobenzoyl Chloride features a benzene ring with a carbonyl chloride group, a bromine atom at the para-position, and a fluorine atom at the ortho-position. This specific arrangement of halogens and the reactive acyl chloride group imparts distinct chemical characteristics. Its physical state is typically described as a white to light yellow liquid or fused solid, with a defined melting point of 24-24.5 °C. Understanding these basic properties is fundamental for chemists when planning reactions or specifying purchase orders for this material.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride commonly involves the conversion of the corresponding carboxylic acid. The process typically utilizes chlorinating agents such as thionyl chloride (SOCl2) or oxalyl chloride (COCl2) in the presence of a catalyst like dimethylformamide (DMF). The reaction is performed under anhydrous conditions to ensure efficient conversion to the acyl chloride. For manufacturers, optimizing these 4-bromo-2-fluorobenzoyl chloride synthesis routes is critical for ensuring product quality and cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD., as a manufacturer in China, is dedicated to maintaining high standards in its production processes.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is largely defined by its acyl chloride functionality. It readily undergoes nucleophilic substitution reactions with various nucleophiles, including amines, alcohols, and thiols, forming amides, esters, and thioesters, respectively. These reactions are fundamental in the synthesis of numerous organic compounds. Additionally, it can participate in Friedel-Crafts acylation, introducing the 4-bromo-2-fluorobenzoyl group into other aromatic systems. These well-established reaction pathways make it a versatile tool for chemists. The availability of this compound through suppliers like NINGBO INNO PHARMCHEM CO.,LTD. facilitates access to critical reagents for research.
The applications of 4-Bromo-2-fluorobenzoyl Chloride span several vital sectors. In the pharmaceutical industry, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), contributing to the development of new therapies. Its presence in agrochemical formulations helps in creating effective pesticides and herbicides. Furthermore, in material science, it can be utilized in the synthesis of specialty polymers and advanced materials. The consistent demand for high-quality 4-bromo-2-fluorobenzoyl chloride underscores its importance in driving chemical innovation across these diverse fields. NINGBO INNO PHARMCHEM CO.,LTD. is committed to meeting this demand with reliable product supply.
The molecular structure of 4-Bromo-2-fluorobenzoyl Chloride features a benzene ring with a carbonyl chloride group, a bromine atom at the para-position, and a fluorine atom at the ortho-position. This specific arrangement of halogens and the reactive acyl chloride group imparts distinct chemical characteristics. Its physical state is typically described as a white to light yellow liquid or fused solid, with a defined melting point of 24-24.5 °C. Understanding these basic properties is fundamental for chemists when planning reactions or specifying purchase orders for this material.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride commonly involves the conversion of the corresponding carboxylic acid. The process typically utilizes chlorinating agents such as thionyl chloride (SOCl2) or oxalyl chloride (COCl2) in the presence of a catalyst like dimethylformamide (DMF). The reaction is performed under anhydrous conditions to ensure efficient conversion to the acyl chloride. For manufacturers, optimizing these 4-bromo-2-fluorobenzoyl chloride synthesis routes is critical for ensuring product quality and cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD., as a manufacturer in China, is dedicated to maintaining high standards in its production processes.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is largely defined by its acyl chloride functionality. It readily undergoes nucleophilic substitution reactions with various nucleophiles, including amines, alcohols, and thiols, forming amides, esters, and thioesters, respectively. These reactions are fundamental in the synthesis of numerous organic compounds. Additionally, it can participate in Friedel-Crafts acylation, introducing the 4-bromo-2-fluorobenzoyl group into other aromatic systems. These well-established reaction pathways make it a versatile tool for chemists. The availability of this compound through suppliers like NINGBO INNO PHARMCHEM CO.,LTD. facilitates access to critical reagents for research.
The applications of 4-Bromo-2-fluorobenzoyl Chloride span several vital sectors. In the pharmaceutical industry, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), contributing to the development of new therapies. Its presence in agrochemical formulations helps in creating effective pesticides and herbicides. Furthermore, in material science, it can be utilized in the synthesis of specialty polymers and advanced materials. The consistent demand for high-quality 4-bromo-2-fluorobenzoyl chloride underscores its importance in driving chemical innovation across these diverse fields. NINGBO INNO PHARMCHEM CO.,LTD. is committed to meeting this demand with reliable product supply.
Perspectives & Insights
Bio Analyst 88
“The availability of this compound through suppliers like NINGBO INNO PHARMCHEM CO.”
Nano Seeker Pro
“In the pharmaceutical industry, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), contributing to the development of new therapies.”
Data Reader 7
“Its presence in agrochemical formulations helps in creating effective pesticides and herbicides.”