Exploring the Applications of 4-Bromo-2-fluorobenzoyl Chloride in Chemical Synthesis
In the dynamic landscape of chemical synthesis, the role of specialized intermediates cannot be overstated. 4-Bromo-2-fluorobenzoyl Chloride, a compound with the CAS number 151982-51-3, is a prime example of such a versatile and essential building block. Its unique chemical structure, characterized by a benzoyl chloride backbone substituted with both bromine and fluorine atoms, enables a broad range of chemical transformations. This article aims to explore the multifaceted applications of this important chemical intermediate, providing insights into its utility in pharmaceutical development, agrochemical production, and advanced organic chemistry.
The physical and chemical properties of 4-Bromo-2-fluorobenzoyl Chloride are critical to its effective utilization. It typically appears as a white to pale yellow liquid or fused solid, with a defined melting point around 24-24.5°C. The presence of the highly reactive acyl chloride group makes it susceptible to hydrolysis, requiring careful handling and storage under anhydrous conditions. Its molecular formula, C7H3BrClFO, and molecular weight of approximately 237.45 g/mol are key identifiers for procurement and quality control. Understanding these attributes is the first step in integrating this compound into any complex synthetic strategy.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride usually involves the conversion of its corresponding carboxylic acid, 4-bromo-2-fluorobenzoic acid, into the acyl chloride. This transformation is commonly achieved using chlorinating agents like thionyl chloride or oxalyl chloride, often with the addition of a catalyst such as DMF. The reaction conditions are typically anhydrous and may involve heating to ensure complete conversion. For manufacturers, the efficiency and purity achieved in these 4-bromo-2-fluorobenzoyl chloride synthesis processes directly impact the quality of the final product. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes high purity in its manufacturing processes, ensuring reliable supply for global research needs.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is centered around its acyl chloride group, which readily participates in nucleophilic acyl substitution reactions. This enables the formation of amides with amines, esters with alcohols, and thioesters with thiols. These reactions are fundamental in constructing larger organic molecules. Furthermore, its use in Friedel-Crafts acylation allows for the attachment of the 4-bromo-2-fluorobenzoyl group to other aromatic systems, expanding its utility in organic synthesis. The ability to perform these transformations highlights its value as a key intermediate.
The applications of 4-Bromo-2-fluorobenzoyl Chloride are extensive across various industries. In the pharmaceutical sector, it serves as a crucial precursor for synthesizing a variety of active pharmaceutical ingredients (APIs), contributing to the development of novel drug candidates. Its specific structural features can impart beneficial properties to the resulting molecules. In the agrochemical industry, it is employed in the creation of effective pesticides and herbicides, supporting modern agricultural practices. Moreover, it finds applications in material science for developing specialized polymers and functional materials. The consistent demand for this compound reflects its significant role in advancing chemical synthesis and innovation. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier, ensuring consistent quality and availability for these critical applications.
The physical and chemical properties of 4-Bromo-2-fluorobenzoyl Chloride are critical to its effective utilization. It typically appears as a white to pale yellow liquid or fused solid, with a defined melting point around 24-24.5°C. The presence of the highly reactive acyl chloride group makes it susceptible to hydrolysis, requiring careful handling and storage under anhydrous conditions. Its molecular formula, C7H3BrClFO, and molecular weight of approximately 237.45 g/mol are key identifiers for procurement and quality control. Understanding these attributes is the first step in integrating this compound into any complex synthetic strategy.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride usually involves the conversion of its corresponding carboxylic acid, 4-bromo-2-fluorobenzoic acid, into the acyl chloride. This transformation is commonly achieved using chlorinating agents like thionyl chloride or oxalyl chloride, often with the addition of a catalyst such as DMF. The reaction conditions are typically anhydrous and may involve heating to ensure complete conversion. For manufacturers, the efficiency and purity achieved in these 4-bromo-2-fluorobenzoyl chloride synthesis processes directly impact the quality of the final product. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes high purity in its manufacturing processes, ensuring reliable supply for global research needs.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is centered around its acyl chloride group, which readily participates in nucleophilic acyl substitution reactions. This enables the formation of amides with amines, esters with alcohols, and thioesters with thiols. These reactions are fundamental in constructing larger organic molecules. Furthermore, its use in Friedel-Crafts acylation allows for the attachment of the 4-bromo-2-fluorobenzoyl group to other aromatic systems, expanding its utility in organic synthesis. The ability to perform these transformations highlights its value as a key intermediate.
The applications of 4-Bromo-2-fluorobenzoyl Chloride are extensive across various industries. In the pharmaceutical sector, it serves as a crucial precursor for synthesizing a variety of active pharmaceutical ingredients (APIs), contributing to the development of novel drug candidates. Its specific structural features can impart beneficial properties to the resulting molecules. In the agrochemical industry, it is employed in the creation of effective pesticides and herbicides, supporting modern agricultural practices. Moreover, it finds applications in material science for developing specialized polymers and functional materials. The consistent demand for this compound reflects its significant role in advancing chemical synthesis and innovation. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier, ensuring consistent quality and availability for these critical applications.
Perspectives & Insights
Nano Explorer 01
“This enables the formation of amides with amines, esters with alcohols, and thioesters with thiols.”
Data Catalyst One
“Furthermore, its use in Friedel-Crafts acylation allows for the attachment of the 4-bromo-2-fluorobenzoyl group to other aromatic systems, expanding its utility in organic synthesis.”
Chem Thinker Labs
“The ability to perform these transformations highlights its value as a key intermediate.”