The foundation of innovative chemical synthesis lies in the availability of versatile and high-quality intermediates. 5-Bromo-4-methylpyridine-2-carboxylic acid, a compound with the CAS number 886365-02-2, has emerged as a significant player in this domain, offering a unique structural motif and reactivity profile that is highly prized by chemists across various disciplines. This article explores the properties and diverse applications of this key intermediate, highlighting its importance in modern synthetic chemistry and providing guidance for procurement.

Chemically defined as 5-Bromo-4-methylpyridine-2-carboxylic acid, this compound typically presents as a white solid, indicating a certain level of purity and stability suitable for chemical reactions. Its molecular structure incorporates a pyridine ring, a common heterocycle found in numerous bioactive molecules, functionalized with a bromine atom and a methyl group. The presence of a carboxylic acid moiety further enhances its synthetic utility, providing a site for derivatization and coupling reactions.

The primary role of 5-Bromo-4-methylpyridine-2-carboxylic acid is as an intermediate in organic synthesis. Its applications are broad and impactful:

1. Pharmaceutical Synthesis: The pyridine ring is a prevalent scaffold in many pharmaceutical drugs. The bromine atom on this intermediate serves as an excellent handle for palladium-catalyzed cross-coupling reactions, enabling medicinal chemists to introduce a wide array of functional groups and build complex molecular structures. This is critical for the discovery and development of new therapeutic agents targeting various diseases. The carboxylic acid group can also be modified to form amides or esters, commonly found in drug molecules.

2. Agrochemical Development: Similar to pharmaceuticals, the agrochemical industry relies on sophisticated organic molecules for crop protection and enhancement. Pyridine derivatives are often found in herbicides, insecticides, and fungicides. 5-Bromo-4-methylpyridine-2-carboxylic acid can serve as a key building block for synthesizing novel agrochemicals, contributing to more effective and environmentally conscious solutions in agriculture.

3. Specialty Chemicals and Materials: Beyond life sciences, this intermediate can also be employed in the synthesis of specialty chemicals and advanced materials where its specific structural features are advantageous. This could include applications in electronics, dyes, or functional polymers.

For researchers and procurement specialists looking to acquire this compound, attention to detail regarding specifications is crucial. A high assay (typically ≥98.0%) and a low moisture content (≤0.5%) are indicative of quality. When seeking to buy 5-Bromo-4-methylpyridine-2-carboxylic acid, partnering with a reputable manufacturer or supplier, especially one based in China known for its chemical production capabilities, is advisable. Procurement managers should solicit quotes, inquire about packaging options (e.g., 25 kg drums), and ensure the supplier can provide necessary documentation like CoA and SDS. The ability to obtain samples is also a valuable step for R&D evaluation. Securing a reliable source for this versatile intermediate is key to accelerating innovation and ensuring the efficiency of synthetic processes.