In the realm of organic chemistry, intermediates are the unsung heroes that enable the construction of complex and vital molecules. Among these, heterocyclic compounds, particularly those containing nitrogen, are of immense interest due to their widespread presence in biologically active substances. 5-Bromo-4-methylpyridine-2-carboxylic acid stands out as a prime example of such a valuable intermediate. With its well-defined structure and reactive functional groups, it offers chemists a versatile platform for synthesis, finding applications in sectors ranging from pharmaceuticals to agrochemicals.

The chemical identity of this compound is clearly defined by its name: 5-Bromo-4-methylpyridine-2-carboxylic acid. Its CAS number, 886365-02-2, serves as a unique identifier in the chemical industry. Physically, it is typically presented as a white solid, a characteristic that simplifies handling and storage in laboratories and manufacturing facilities. The purity level, often specified at ≥98.0% assay, ensures that it can be effectively utilized in demanding synthetic protocols where impurity profiles can significantly impact reaction outcomes and product quality.

The true value of 5-Bromo-4-methylpyridine-2-carboxylic acid lies in its inherent chemical versatility. The pyridine ring itself is a common pharmacophore, meaning it is a structural feature responsible for the biological activity of many drugs. The bromine atom at the 5-position is strategically placed to facilitate a variety of palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are cornerstone methodologies in modern organic synthesis, allowing for the formation of new carbon-carbon bonds and the construction of complex molecular architectures. The methyl group at the 4-position can influence steric and electronic properties, potentially tuning the reactivity or biological activity of the final molecule.

The carboxylic acid group at the 2-position is another highly reactive handle. It can be easily converted into esters, amides, acid halides, or reduced to alcohols, providing further pathways for functionalization and diversification. This dual functionality—the reactive bromine and the modifiable carboxylic acid—makes 5-Bromo-4-methylpyridine-2-carboxylic acid an exceptionally useful building block for medicinal chemists and organic synthesis experts.

Sourcing this intermediate involves engaging with reputable manufacturers and suppliers. Companies that specialize in fine chemicals and intermediates, often based in China, are key players in the global supply chain. When procuring this compound, it is important for buyers to consider the supplier’s reliability, adherence to quality standards, and competitive pricing. Requesting a quote and product samples allows R&D teams to verify the material's suitability for their specific synthetic needs. For larger-scale operations, understanding the supplier’s production capacity and logistics is also critical. The consistent availability of high-purity 5-Bromo-4-methylpyridine-2-carboxylic acid is essential for advancing research and development projects in the chemical sciences.