The Chemical Profile of Acryloyl Chloride: Properties, Manufacturing & Uses
Acryloyl chloride, identified by its CAS number 814-68-6 and chemical formula C3H3ClO, is a highly reactive organic compound that plays a significant role across various industrial sectors, most notably in the synthesis of pharmaceuticals like Ibrutinib. As a member of the acid chloride family, it is characterized by its colorless liquid appearance and a distinct, pungent odor. Its manufacturing typically involves the chlorination of acrylic acid, a process that yields a substance known for its potent acylating capabilities.
The physical and chemical properties of acryloyl chloride are central to its utility. With a density of approximately 1.1 g/cm³ and a boiling point of around 75.5 °C at standard atmospheric pressure, it is a volatile compound. Its flash point is relatively low, around 16.1 °C, indicating its flammability. The high reactivity of the acid chloride group makes it an excellent reagent for introducing the acryloyl moiety into other molecules, a critical step in many synthetic pathways.
In the pharmaceutical industry, acryloyl chloride is particularly valued as an intermediate. Its role in the synthesis of Ibrutinib is well-documented, where it is used in the final acylation step. This demand for Ibrutinib drives a consistent need for high-quality acryloyl chloride. Manufacturers often rely on specialized suppliers to ensure the purity and consistency of this essential chemical.
Beyond pharmaceuticals, acryloyl chloride serves as a valuable building block in the creation of polymers and other organic chemicals. Its ability to undergo addition reactions makes it suitable for producing various acrylate-based polymers and copolymers with tailored properties for applications ranging from coatings to specialized materials. However, due to its toxic and lachrymatory nature, strict safety measures are imperative during its handling and application. Proper industrial hygiene and safety protocols are non-negotiable when working with acryloyl chloride, ensuring the well-being of personnel and the environment.
The physical and chemical properties of acryloyl chloride are central to its utility. With a density of approximately 1.1 g/cm³ and a boiling point of around 75.5 °C at standard atmospheric pressure, it is a volatile compound. Its flash point is relatively low, around 16.1 °C, indicating its flammability. The high reactivity of the acid chloride group makes it an excellent reagent for introducing the acryloyl moiety into other molecules, a critical step in many synthetic pathways.
In the pharmaceutical industry, acryloyl chloride is particularly valued as an intermediate. Its role in the synthesis of Ibrutinib is well-documented, where it is used in the final acylation step. This demand for Ibrutinib drives a consistent need for high-quality acryloyl chloride. Manufacturers often rely on specialized suppliers to ensure the purity and consistency of this essential chemical.
Beyond pharmaceuticals, acryloyl chloride serves as a valuable building block in the creation of polymers and other organic chemicals. Its ability to undergo addition reactions makes it suitable for producing various acrylate-based polymers and copolymers with tailored properties for applications ranging from coatings to specialized materials. However, due to its toxic and lachrymatory nature, strict safety measures are imperative during its handling and application. Proper industrial hygiene and safety protocols are non-negotiable when working with acryloyl chloride, ensuring the well-being of personnel and the environment.
Perspectives & Insights
Core Pioneer 24
“This demand for Ibrutinib drives a consistent need for high-quality acryloyl chloride.”
Silicon Explorer X
“Manufacturers often rely on specialized suppliers to ensure the purity and consistency of this essential chemical.”
Quantum Catalyst AI
“Beyond pharmaceuticals, acryloyl chloride serves as a valuable building block in the creation of polymers and other organic chemicals.”