Understanding the fundamental chemical properties and synthesis methods of a compound is crucial for its effective application in research and industry. 1,4-Dioxaspiro[4.5]decan-8-one (CAS 4746-97-8), a key fine chemical intermediate, offers a fascinating case study in organic chemistry. This article explores its core characteristics and common synthesis pathways, providing valuable information for chemists and procurement professionals.

Chemical Identity and Physical Characteristics

Known scientifically as 1,4-dioxaspiro[4.5]decan-8-one, and often referred to as 1,4-Cyclohexanedione monoethylene acetal, this compound is identified by its CAS number 4746-97-8. Its molecular formula is C8H12O3. Physically, it typically presents as a white to beige crystalline powder or crystals. Key physical properties include a melting point of 70-73 °C and a density of approximately 1.0887. It is soluble in solvents like chloroform and methanol, which is advantageous for reaction setup. Importantly, it is classified as moisture and light-sensitive, requiring appropriate storage conditions such as a cool, dark place under an inert atmosphere.

Synthesis Routes and Reactivity

The synthesis of 1,4-Dioxaspiro[4.5]decan-8-one commonly involves the reaction of 1,4-cyclohexanedione with ethylene glycol under acidic catalysis to form the cyclic ketal. This process is a standard method for protecting carbonyl groups, providing a stable intermediate that can undergo further transformations. The compound's reactivity is largely dictated by the presence of the ketone group, which can participate in various nucleophilic addition and condensation reactions after deprotection. Its spirocyclic nature also influences its stereochemical outcomes in subsequent reactions.

Applications and Sourcing Insights

The applications of 1,4-Dioxaspiro[4.5]decan-8-one are diverse, ranging from its use as an intermediate in the synthesis of analgesic compounds to its role as a building block for specialized research probes. For those looking to buy 1,4-Dioxaspiro[4.5]decan-8-one, sourcing from reliable chemical suppliers, especially manufacturers in China, is recommended. When you purchase 1,4-Dioxaspiro[4.5]decan-8-one, ensure you verify purity levels (often >98%) and consult suppliers for specific handling and storage recommendations. Understanding the price from various manufacturers will aid in making an informed purchasing decision.

By understanding its chemical properties and synthesis, chemists can better utilize 1,4-Dioxaspiro[4.5]decan-8-one in their synthetic endeavors. Partnering with reputable suppliers ensures access to this valuable intermediate for your research and manufacturing needs.