Azepane, a cyclic secondary amine identified by CAS number 111-49-9, is a compound of significant interest in the chemical and pharmaceutical industries. Characterized by its colorless to light yellow liquid appearance, Azepane offers a unique set of physical and chemical properties that make it an indispensable building block for various complex molecules. This article will explore these properties and its diverse applications, with a particular focus on its role as a pharmaceutical intermediate, and highlight the advantages of sourcing from a reputable manufacturer.

From a physical standpoint, Azepane presents as a liquid at room temperature, with a melting point of -37°C and a boiling point of approximately 142.7°C at 760 mmHg. Its density is around 0.8 g/cm³, and it possesses a flash point of 18.3°C, indicating its flammability. These physical characteristics are essential for handling, storage, and processing in industrial settings. The chemical formula C6H13N and a molecular weight of 99.174 g/mol further define its molecular structure and reactivity. A typical specification for Azepane from manufacturers includes an assay of ≥98.0%, ensuring high purity for demanding applications.

The primary chemical utility of Azepane lies in its functionality as a secondary amine. This allows it to participate in a wide array of organic reactions, including nucleophilic substitutions, amide formations, and as a base in various catalytic processes. Its cyclic structure introduces a degree of rigidity, which can be advantageous in designing molecules with specific three-dimensional conformations. This makes it a versatile intermediate, particularly in the synthesis of biologically active compounds.

A prime example of Azepane's application is in the pharmaceutical industry, where it serves as a critical intermediate for the synthesis of drugs such as Bazedoxifene. Bazedoxifene, a SERM, relies on the azepane moiety for its therapeutic efficacy in treating conditions like osteoporosis. The demand for such pharmaceuticals drives the need for reliable, high-quality Azepane suppliers. When purchasing Azepane, especially for pharmaceutical use, verifying its purity and sourcing from an established manufacturer in China or elsewhere ensures compliance and product integrity.

Beyond pharmaceuticals, Azepane's reactive nature makes it valuable in broader organic synthesis and potentially in the development of agrochemicals or specialty polymers. Researchers and formulators looking to buy Azepane for novel applications can leverage its versatile chemistry. The compound is typically supplied in 200 kg drums, but suppliers often offer flexibility in packaging for bulk orders. Understanding these details is crucial when planning procurement strategies for Hexahydroazepine or Hexamethyleneamine.

In conclusion, Azepane's combination of physical and chemical properties makes it a highly sought-after intermediate. Its established role in pharmaceutical synthesis, coupled with its potential in other chemical sectors, underscores its importance. For companies seeking a dependable source for this compound, engaging with manufacturers who can guarantee purity, offer flexible packaging, and provide competitive Azepane price is key to successful operations.