The landscape of modern chemical synthesis is constantly evolving, with specialized intermediates playing a critical role in the creation of advanced compounds. 3-Bromobenzotrifluoride, bearing the CAS number 401-78-5, is one such intermediate, highly prized for its unique structural features and broad applicability. This article explores the chemistry behind this compound, including its synthesis and its significant roles in various industrial applications, with a focus on providing insights for procurement managers and R&D scientists seeking reliable sources.

Synthesis and Properties of 3-Bromobenzotrifluoride

3-Bromobenzotrifluoride is typically synthesized through established chemical routes involving the bromination of benzotrifluoride or related precursors. As a clear, colorless to slightly yellow liquid, its physical properties include a boiling point of approximately 151-152°C and a density of 1.61 g/mL at 25°C. Its molecular structure, C7H4BrF3, features a trifluoromethyl group that significantly influences its electronic properties and reactivity. This trifluoromethyl group is a strong electron-withdrawing substituent, impacting the reactivity of the aromatic ring and the carbon-bromine bond. This electronic influence makes 3-Bromobenzotrifluoride an excellent substrate for various coupling reactions, particularly those catalyzed by palladium, which are fundamental to modern organic synthesis.

Key Applications in Industry

The versatility of 3-Bromobenzotrifluoride makes it a crucial intermediate across several major industries:

  • Pharmaceutical Development: It is extensively used in the synthesis of Active Pharmaceutical Ingredients (APIs). The incorporation of the trifluoromethyl moiety into drug molecules is a common strategy to enhance properties such as metabolic stability, lipophilicity, and target binding affinity. Pharmaceutical companies rely on high-purity 3-Bromobenzotrifluoride to ensure the efficacy and safety of their drug candidates.
  • Agrochemical Production: In the agrochemical sector, this compound serves as a building block for novel pesticides, herbicides, and fungicides. The trifluoromethyl group can improve the efficacy and persistence of these crop protection agents, leading to more effective agricultural solutions.
  • Materials Science: Beyond pharmaceuticals and agrochemicals, 3-Bromobenzotrifluoride finds applications in the synthesis of specialty materials, including liquid crystals, polymers, and electronic chemicals, where its unique properties are advantageous.

Sourcing Strategies for 3-Bromobenzotrifluoride

For businesses looking to purchase 3-Bromobenzotrifluoride (CAS 401-78-5), partnering with a reputable manufacturer is key. As a dedicated supplier from China, we offer high-purity material, competitive pricing, and reliable supply chain management. When inquiring about purchasing this chemical, it is advisable to:

  • Verify Purity: Ensure the product meets the required purity specifications, typically 98% or higher, through detailed COAs.
  • Assess Supplier Capabilities: Look for manufacturers with proven production capacity and a strong commitment to quality control.
  • Obtain Competitive Quotes: Compare pricing from reliable sources and consider bulk purchasing for better cost efficiencies.

In conclusion, 3-Bromobenzotrifluoride (CAS 401-78-5) is a critical intermediate whose chemical properties enable significant advancements in pharmaceuticals, agrochemicals, and materials science. By sourcing from experienced manufacturers, companies can ensure access to high-quality material essential for their innovative endeavors.