1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole, or MSNT (CAS 74257-00-4), is a fascinating compound whose molecular architecture dictates its powerful role as a condensing reagent in chemical synthesis. As a leading 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. delves into the chemical nuances that make MSNT so valuable.

The molecular structure of MSNT features a 1,2,4-triazole ring substituted with a nitro group and a mesitylene-2-sulfonyl group. This combination imbues the molecule with specific electronic and steric properties crucial for its function. The mesitylene-2-sulfonyl moiety, with its bulky methyl groups, can influence the regioselectivity and reactivity of certain reactions, while the electron-withdrawing nitro group on the triazole ring activates it for nucleophilic attack or facilitates its role as a leaving group precursor in condensation reactions. The molecular formula C11H12N4O4S and a molecular weight of 296.30 g/mol are key identifiers for this compound.

MSNT's primary application as a condensing reagent, especially in oligonucleotide synthesis via the phosphotriester method, leverages the reactivity of its sulfonyl group. It effectively activates hydroxyl or phosphate groups, facilitating the formation of ester bonds. This makes it indispensable for constructing DNA and RNA sequences with high fidelity. The compound's typical presentation as a pale yellow crystalline powder with a purity of ≥98.0% by HPLC assures chemists of its reliable performance in complex synthesis pathways.

Understanding the chemistry of MSNT is crucial for optimizing its use. NINGBO INNO PHARMCHEM CO.,LTD., as a prominent 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole supplier in China, is committed to providing not just the chemical itself, but also the understanding of its application. Our dedication to quality ensures that the MSNT we supply meets the stringent requirements for advanced organic synthesis and biochemical research. By providing high-purity MSNT, we empower scientists to explore new molecular frontiers and develop innovative solutions in fields ranging from genetic engineering to materials science.

The consistent quality and well-defined chemical properties of MSNT make it a sought-after reagent for both academic and industrial laboratories. As a key MSNT manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. remains at the forefront of supplying this essential compound, contributing to the ongoing advancements in synthetic chemistry.