In the dynamic field of life sciences, precise molecular manipulation is key to unlocking new discoveries and developing innovative technologies. For researchers and product developers seeking robust methods for connecting biomolecules, Disuccinimidyl Glutarate (DSG) stands out as a highly effective homobifunctional crosslinking reagent. As a reputable manufacturer and supplier based in China, we are dedicated to providing high-quality DSG that meets the demanding standards of modern biochemical research and development.

Understanding Disuccinimidyl Glutarate (DSG)

Disuccinimidyl Glutarate, identified by its CAS number 79642-50-5, is a versatile crosslinker characterized by two N-hydroxysuccinimide (NHS) ester functional groups. These groups are strategically placed at either end of a short, five-atom spacer arm. This structural design allows DSG to efficiently react with primary amines, commonly found in lysine residues and the N-termini of proteins and peptides. The reaction results in the formation of stable amide bonds, a crucial feature for creating durable bioconjugates.

Key Applications Driving Innovation

The utility of DSG extends across a broad spectrum of critical applications:

  • Protein-Protein Crosslinking: DSG is invaluable for stabilizing protein complexes, enabling researchers to investigate protein-protein interactions, study molecular structures, and understand cellular signaling pathways. Whether for in vitro studies or intracellular applications, its membrane permeability is a significant advantage. If you are looking to purchase DSG for protein studies, consider our reliable supply.
  • Antibody-Drug Conjugates (ADCs): In the pharmaceutical sector, DSG can act as a linker to attach therapeutic payloads to antibodies, forming ADCs that target specific cells, such as cancer cells. This targeted approach enhances treatment efficacy while minimizing side effects. Sourcing high-purity DSG is essential for the quality of these complex biotherapeutics.
  • Chromatin Immunoprecipitation (ChIP) Assays: DSG plays a vital role in ChIP assays by crosslinking DNA-bound proteins to DNA. This crucial step preserves protein-DNA interactions, improving the detection and analysis of transcription factors and other DNA-binding proteins. Researchers frequently buy DSG to optimize their ChIP protocols for greater accuracy.
  • Surface Functionalization: For applications in diagnostics, biosensing, and affinity chromatography, DSG can be used to immobilize biomolecules onto various surfaces, creating functionalized substrates. Our quality DSG is an excellent choice for these surface modification strategies.

Why Choose Our Disuccinimidyl Glutarate?

As a trusted manufacturer and supplier, we pride ourselves on offering Disuccinimidyl Glutarate with superior purity (typically exceeding 97%) and exceptional batch-to-batch consistency. We understand the importance of reliable reagents in scientific discovery and product development. Our commitment to quality, competitive pricing, and efficient logistics makes us your ideal partner for purchasing essential biochemicals. We cater to diverse needs, from small-scale research to larger industrial demands, ensuring you can buy the DSG you need, when you need it.

For researchers and developers looking for a dependable supplier of high-quality Disuccinimidyl Glutarate, we offer a solution that combines chemical expertise with robust manufacturing capabilities. Explore how our DSG can advance your projects in bioconjugation, protein modification, and beyond. Contact us today to get a quote or place your order.