In the realm of molecular biology and biotechnology, the synthesis and manipulation of nucleic acids are fundamental. When working with thiolated DNA, a common challenge is the tendency for terminal sulfur atoms to dimerize, especially in the presence of oxygen. This dimerization significantly impedes the efficiency of critical coupling reaction experiments, such as the immobilization of DNA onto biosensor surfaces or the incorporation of modified nucleotides. To combat this, Dithiothreitol (DTT) emerges as an indispensable tool.

DTT functions as a potent reducing agent that effectively breaks these unwanted disulfide bridges formed between thiolated DNA molecules. By adding DTT to the DNA solution and subsequently removing it after a controlled reaction period, researchers can dramatically reduce dimerization. This restoration of free thiol groups ensures that the DNA remains in its active, monomeric form, ready for subsequent conjugation or hybridization processes. As a dedicated DTT manufacturer and supplier, we understand the precision required in these applications.

Our commitment as a DTT supplier in China is to provide materials of exceptional purity and consistency. When you buy DTT for your DNA synthesis needs, you can trust that you are receiving a product that meets rigorous quality standards, ensuring optimal performance and reproducible results. The DTT (CAS 3483-12-3) we offer is characterized by its high assay, typically above 98%, making it ideal for sensitive molecular biology workflows.

The strategic use of DTT not only enhances the success rate of DNA-based biotechnologies but also contributes to the cost-effectiveness of research and development. By preventing dimerization, it reduces the need for costly re-synthesis or purification steps. We encourage scientists and procurement managers to inquire about our DTT prices and bulk purchase options. Partner with a reliable DTT manufacturer to secure the integrity and efficiency of your thiolated DNA applications.