For organic chemists, the power of synthesis lies in selecting the right building blocks and employing them strategically. 2-Chloro-4-iodotoluene (CAS 83846-48-4) stands out as a versatile and valuable intermediate, offering a platform for a wide array of synthetic transformations that are crucial for developing novel compounds across industries.

The Reactivity Toolkit of 2-Chloro-4-iodotoluene

2-Chloro-4-iodotoluene, with its molecular formula C7H6ClI, is characterized by a unique substitution pattern on a toluene ring. The key to its utility lies in the differing reactivities of the chlorine and iodine substituents. The iodine atom, being a better leaving group than chlorine, preferentially participates in many important reactions, especially those catalyzed by transition metals.

Chemists frequently leverage 2-Chloro-4-iodotoluene in:

  • Palladium-Catalyzed Cross-Coupling Reactions: This is perhaps the most significant application. Reactions like the Suzuki-Miyaura coupling (with boronic acids), Heck reaction (with alkenes), Sonogashira coupling (with alkynes), and Stille coupling (with organostannanes) allow for the efficient formation of new carbon-carbon bonds. These reactions are fundamental to building complex organic scaffolds found in pharmaceuticals, agrochemicals, and advanced materials.
  • Nucleophilic Aromatic Substitution (SNAr): While less common for simple aryl halides, the presence of multiple halogens and the methyl group can influence the regioselectivity and reactivity towards certain nucleophiles under specific conditions.
  • Metal-Halogen Exchange: The iodine atom can undergo facile metal-halogen exchange, for example, with organolithium or Grignard reagents, to generate arylmetal species. These organometallic intermediates are themselves powerful nucleophiles for further synthetic steps.

The compound's typical form as a light yellow liquid with a purity of 97%+ ensures good handling and reactivity in most organic synthesis settings. Proper storage—in a cool, dry, and dark environment—is vital to maintain its integrity and reactivity.

Applications Beyond the Bench

Beyond its direct use in research and development, 2-Chloro-4-iodotoluene serves as a critical intermediate for manufacturing purposes. It is a precursor for:

  • Pharmaceutical Intermediates: Essential for constructing complex drug molecules targeting various diseases.
  • Electronic Materials: Building blocks for organic semiconductors, OLED materials, and other functional organic electronic components.

When you buy 2-Chloro-4-iodotoluene, ensuring high purity and reliable sourcing from a trusted 2-Chloro-4-iodotoluene manufacturer is key to achieving successful outcomes in your synthesis.

Where to Purchase for Your Synthesis Needs

As chemists, we understand the importance of quality raw materials. When you need to purchase 2-Chloro-4-iodotoluene, look to experienced suppliers who can provide the necessary technical specifications and support. Many manufacturers in China are well-positioned to supply this vital intermediate, often at competitive prices.

We are a leading manufacturer dedicated to providing high-purity intermediates like 2-Chloro-4-iodotoluene (CAS 83846-48-4). Our commitment is to support your synthetic endeavors with quality products and reliable service. Contact us to discuss your specific requirements, inquire about pricing, and secure your supply of this indispensable organic synthesis building block.

Leverage our expertise as a premier manufacturer and supplier of 2-Chloro-4-iodotoluene (CAS 83846-48-4). Reach out for a quote and to discuss how our product can enhance your organic synthesis projects.