For chemists, researchers, and procurement specialists involved in fine chemical synthesis, a thorough understanding of a compound's properties is fundamental to its successful application. 2-Chloro-4-iodotoluene, identified by its CAS number 83846-48-4, is a valuable intermediate whose utility is directly tied to its distinct chemical and physical characteristics.

Unpacking the Properties of 2-Chloro-4-iodotoluene

2-Chloro-4-iodotoluene is an organohalogen compound with the molecular formula C7H6ClI and a molecular weight of 252.48 g/mol. Its structure features a toluene ring substituted with a chlorine atom at the ortho position and an iodine atom at the para position relative to the methyl group. This arrangement dictates its reactivity and physical behavior.

Key physical properties include:

  • Appearance: Typically observed as a light yellow liquid.
  • Melting Point: Approximately 22°C. This means it can transition between liquid and solid states at or near room temperature, requiring appropriate storage considerations.
  • Boiling Point: Around 241.1°C at standard atmospheric pressure (760 mmHg). This high boiling point is indicative of its relatively low volatility.
  • Density: Reported as 1.8 g/cm³.
  • Flash Point: Approximately 99.6°C, indicating moderate flammability.
  • Refractive Index: Around 1.6211, a parameter useful for identification and purity checks.

Chemical Reactivity and Stability

The chemical value of 2-Chloro-4-iodotoluene stems from the differing reactivity of its halogen substituents. The carbon-iodine bond is significantly weaker and more polarizable than the carbon-chlorine bond. This makes the iodine atom an excellent leaving group, particularly susceptible to:

  • Transition Metal Catalyzed Cross-Coupling Reactions: Such as Suzuki, Stille, Heck, and Sonogashira couplings, which are foundational for carbon-carbon bond formation in complex synthesis.
  • Nucleophilic Substitution: While aromatic substitution is generally difficult, the electron-withdrawing nature of the halogens can activate the ring for certain nucleophilic attacks under specific conditions.

For optimal stability, 2-Chloro-4-iodotoluene should be stored in a dark, sealed container in a dry environment at room temperature. Protecting it from light and moisture helps to prevent degradation and maintain its reactivity for subsequent chemical transformations.

Importance for Synthesis and Sourcing

Understanding these properties is crucial for chemists when designing synthetic routes and for procurement specialists when sourcing this intermediate. The purity, typically specified as 97%+, is critical for achieving good yields and minimizing by-products in sensitive reactions.

When you need to buy 2-Chloro-4-iodotoluene, looking for suppliers who clearly list these detailed specifications is advisable. Many manufacturers in China provide this compound, and choosing a reliable 2-Chloro-4-iodotoluene supplier ensures that your procured material will perform as expected in your synthesis, whether for electronic materials or pharmaceutical intermediates.

Where to Purchase

Procuring high-quality 2-Chloro-4-iodotoluene requires attention to detail. Always check the CAS number (83846-48-4) and ensure the purity meets your project's demands. We, as a leading manufacturer, offer this intermediate with guaranteed specifications, supported by comprehensive technical data. Contact us to learn more about purchasing options and to get a quote for your chemical intermediate needs.

We are a dedicated manufacturer and supplier of 2-Chloro-4-iodotoluene (CAS 83846-48-4). For detailed technical specifications, pricing, and to place an order, please contact us.