The production of essential chemical intermediates like 2-Morpholinoethanol (CAS: 622-40-2) relies on efficient and well-established synthesis pathways. Understanding these routes is key for manufacturers and researchers alike, ensuring a consistent supply of this versatile compound. NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying high-quality 2-Morpholinoethanol, produced through optimized synthetic methodologies.

2-Morpholinoethanol, also known by its synonym 4-Morpholineethanol, is typically synthesized through the reaction of morpholine with ethylene oxide. This nucleophilic addition reaction is a straightforward yet effective method for producing the desired compound. In this process, the nitrogen atom of morpholine attacks the epoxide ring of ethylene oxide, leading to the formation of the hydroxyethyl substituent. The reaction conditions, such as temperature and catalysts, are carefully controlled to maximize yield and purity. For example, controlling the temperature at or below 20°C during the introduction of ethylene oxide gas into morpholine is a common practice cited in its production.

Another significant synthesis method involves the reaction of morpholine with 2-bromoethanol or 2-chloroethanol in the presence of a base. This reaction, often carried out in a suitable solvent like acetonitrile, facilitates the alkylation of the morpholine nitrogen atom. The choice of reactants and reaction conditions, including temperature and reaction time, are critical for achieving high yields and minimizing side products. For instance, reacting morpholine with 2-bromoethanol at 80°C for 72 hours is a documented method to produce 2-Morpholinoethanol.

The availability of reliable information regarding the 2-morpholinoethanol synthesis process is vital for anyone looking to buy 2-Morpholinoethanol for their chemical needs. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its products are manufactured using these optimized and validated synthesis routes, guaranteeing high purity and consistent quality. Familiarity with the 2-morpholinoethanol chemical properties and its synthesis pathways empowers users to confidently incorporate it into their research and manufacturing endeavors, knowing they are working with a well-understood and reliably produced intermediate.