Methyl 4-bromo-3-nitrobenzoate (CAS 2363-16-8): A Versatile Tool for Chemical Researchers
For chemical researchers, the selection of the right starting materials and intermediates can significantly impact the success and efficiency of their experiments. Methyl 4-bromo-3-nitrobenzoate, bearing the CAS number 2363-16-8, is a compound that has emerged as a versatile tool in the arsenal of many a chemist. Its unique chemical properties make it suitable for a broad spectrum of research applications, from fundamental organic synthesis to cutting-edge drug design.
The inherent reactivity of Methyl 4-bromo-3-nitrobenzoate stems from its strategically placed functional groups. The bromine atom on the aromatic ring is a prime candidate for nucleophilic aromatic substitution or, more commonly, for participation in palladium-catalyzed cross-coupling reactions. These reactions are indispensable for building complex carbon frameworks, a common requirement in synthesizing novel molecules. Researchers can readily perform Suzuki-Miyaura coupling, Heck reactions, or Sonogashira couplings using this intermediate to introduce diverse substituents onto the aromatic core, thereby tailoring the properties of the final product.
Beyond its utility in forming new carbon-carbon bonds, the nitro group in Methyl 4-bromo-3-nitrobenzoate offers another avenue for functionalization. Reduction of the nitro group to an amine is a straightforward transformation that yields a primary amine. This amine functionality is highly valuable, as it can be further elaborated into amides, ureas, sulfonamides, or used in the synthesis of heterocycles. These structural motifs are frequently encountered in pharmaceuticals and agrochemicals, highlighting the compound's importance as a research chemical for developing new bioactive compounds.
Furthermore, scientific literature suggests that Methyl 4-bromo-3-nitrobenzoate exhibits properties that make it interesting for drug design, particularly its affinity for copper ions. This characteristic can be exploited in developing metallodrugs or compounds that modulate cellular metal ion uptake. The ability to use this molecule as a scaffold, with controlled conformational flexibility, allows researchers to design more specific and potent therapeutic agents. Consequently, the demand to buy Methyl 4-bromo-3-nitrobenzoate online from reputable suppliers is consistently high among research institutions worldwide.
In essence, Methyl 4-bromo-3-nitrobenzoate is more than just a chemical intermediate; it is a key enabler of scientific discovery. Its multifaceted reactivity and potential applications in drug design and advanced materials synthesis make it an indispensable research chemical, facilitating innovation across various scientific disciplines.
Perspectives & Insights
Bio Analyst 88
“Beyond its utility in forming new carbon-carbon bonds, the nitro group in Methyl 4-bromo-3-nitrobenzoate offers another avenue for functionalization.”
Nano Seeker Pro
“Reduction of the nitro group to an amine is a straightforward transformation that yields a primary amine.”
Data Reader 7
“This amine functionality is highly valuable, as it can be further elaborated into amides, ureas, sulfonamides, or used in the synthesis of heterocycles.”