Neutral Red: A Historical and Modern Perspective in Histology
Histology, the study of the microscopic anatomy of cells and tissues, relies heavily on the precise application of stains to visualize cellular structures and processes. Among the arsenal of stains available to histologists, Neutral Red stands out for its unique properties and historical significance. Known also by its Colour Index name C.I. 50040 or synonyms like Basic Red 5 and Toluylene Red, Neutral Red (CAS 553-24-2) has been a staple in laboratories for decades. As a dedicated chemical supplier, we are proud to offer this essential reagent.
Neutral Red is a cationic phenazine dye that exhibits amphoteric properties, meaning it can act as both an acid and a base. Its most characteristic feature in histological applications is its ability to selectively stain acidic components within cells, most notably the lysosomes. These organelles, responsible for intracellular digestion and waste removal, accumulate Neutral Red, appearing as bright red granules under the microscope. This selective staining makes it invaluable for identifying and characterizing lysosomes, a fundamental aspect of cellular pathology and research.
Historically, Neutral Red has been employed as a general cellular stain, providing contrast and highlighting cellular morphology. It can be used in various staining methods, often as a counterstain in combination with other dyes to differentiate cellular components. Its use in understanding cellular processes like phagocytosis and endocytosis, which involve lysosomal activity, is well-documented. For researchers and institutions looking to buy Neutral Red for histological applications, securing a high-purity product is essential for achieving optimal staining results. We, as a leading manufacturer in China, specialize in providing precisely that.
Furthermore, Neutral Red's ability to indicate pH changes adds another layer to its utility. It transitions from red in acidic environments (pH 6.8) to yellow in more alkaline conditions (pH 8.0). This characteristic is leveraged not only in biochemical assays but also in some specialized histological staining procedures where pH-sensitive visualization is required. The consistency in its performance as a stain and pH indicator makes it a dependable choice for routine laboratory work and cutting-edge research alike.
When considering where to purchase Neutral Red dye, prioritizing quality and reliability is key. We offer Neutral Red powder with guaranteed purity, ensuring that your staining protocols are effective and reproducible. Whether you are performing standard histological preparations or exploring novel cellular mechanisms, our commitment as a trusted supplier of research chemicals ensures you have access to the tools you need. Explore our offerings to buy Neutral Red and enhance your histological studies with confidence.
Perspectives & Insights
Logic Thinker AI
“Histology, the study of the microscopic anatomy of cells and tissues, relies heavily on the precise application of stains to visualize cellular structures and processes.”
Molecule Spark 2025
“Among the arsenal of stains available to histologists, Neutral Red stands out for its unique properties and historical significance.”
Alpha Pioneer 01
“50040 or synonyms like Basic Red 5 and Toluylene Red, Neutral Red (CAS 553-24-2) has been a staple in laboratories for decades.”