For researchers and professionals in the field of peptide synthesis, achieving high yields and maintaining enantiomeric purity are paramount. The process of forming peptide bonds, especially when employing carbodiimide coupling agents like Dicyclohexylcarbodiimide (DCC), is often plagued by side reactions, notably racemization. This unintended loss of stereochemical integrity can render a synthesized peptide inactive or even toxic. Fortunately, the introduction of additives has revolutionized the efficiency and accuracy of peptide bond formation. Among these, 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one, commonly known as HOOBT or HODhbt, stands out as a particularly effective solution.

HOOBT is a heterocyclic organic compound that functions as an effective additive in peptide coupling reactions. Its primary mechanism involves minimizing the risk of racemization of the activated amino acid residue. When an amino acid is activated by a carbodiimide, it can form an O-acylisourea intermediate, which is prone to forming an oxazolone intermediate, leading to racemization. HOOBT intercepts this process. By forming an activated ester with the amino acid, HOOBT provides a more stable intermediate that is less susceptible to forming the oxazolone, thereby preserving the chiral integrity of the amino acid. This makes it an indispensable tool for any chemist aiming to buy HOOBT for peptide synthesis with high enantiopurity.

The benefits of incorporating HOOBT into your peptide synthesis protocols are manifold. Firstly, it significantly enhances the yield of the desired peptide product by reducing the formation of unwanted side products and racemized impurities. This means more of your expensive amino acid precursors are converted into the target peptide, offering a better return on investment. Secondly, by suppressing racemization, HOOBT ensures that the final peptide product possesses the correct stereochemistry, which is critical for its biological activity and therapeutic efficacy. For researchers requiring precise chiral control, sourcing high-purity HOOBT from a reputable supplier in China is a strategic advantage.

When considering the purchase of HOOBT, it is crucial to partner with a reliable manufacturer that guarantees high purity, typically 99% HPLC. This level of purity is essential to ensure that the additive itself does not introduce contaminants or interfere with the sensitive coupling reactions. Understanding the price of HOOBT for DCC coupling is also a key consideration for procurement managers. Competitive pricing, coupled with consistent quality, allows research institutions and pharmaceutical companies to scale their peptide synthesis operations effectively. As a dedicated provider of specialized chemical intermediates, we offer HOOBT to meet these demands, ensuring you can confidently purchase HOOBT for your critical research projects.

In conclusion, 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one is an invaluable additive for modern peptide synthesis. Its ability to improve yields and combat racemization makes it a preferred choice for chemists worldwide. By choosing a quality-conscious manufacturer and supplier, you can leverage the benefits of HOOBT to achieve superior results in your peptide research and development.