For procurement managers and R&D scientists in the chemical and pharmaceutical industries, sourcing high-quality reagents is paramount to successful operations. N,N'-Diisopropylcarbodiimide (DIC), identified by its CAS number 693-13-0, is one such critical reagent whose consistent availability and purity directly influence the outcome of numerous synthesis projects. This article aims to guide buyers on understanding DIC's applications, key quality considerations, and strategies for effective procurement from reputable manufacturers and suppliers.

DIC's primary utility lies in its function as a potent dehydrating and coupling agent. Its most well-known applications include peptide synthesis and esterification reactions. In peptide synthesis, DIC acts as an efficient condensing agent, forming peptide bonds with relative ease and producing a soluble byproduct, diisopropylurea, which simplifies purification. This characteristic is a significant advantage over other carbodiimides that generate less soluble byproducts, making DIC a preferred choice for streamlining complex synthesis protocols. For those looking to buy DIC for peptide research, prioritizing suppliers who can guarantee high purity (typically ≥99%) is essential.

Beyond peptide synthesis, DIC is extensively used in the preparation of various organic compounds, including acid anhydrides, aldehydes, ketones, and isocyanates. It is also a key reagent in the synthesis of specific pharmaceutical intermediates, such as amikacin and glutathione. The ability of DIC to function under relatively mild conditions contributes to its widespread adoption in sectors where precision and reliability are critical. When evaluating potential suppliers, understanding their production capacity and quality control measures is crucial. Asking about their ability to provide Certificate of Analysis (CoA) for each batch is a standard practice.

When considering the procurement of N,N'-Diisopropylcarbodiimide, buyers should focus on several key factors. Firstly, purity is non-negotiable. A purity assay of 99% or higher, verified by Gas Chromatography (GC), is generally required for most demanding applications. Secondly, the physical form is important; DIC is a colorless to yellowish liquid, and its consistent appearance is an indicator of quality. Thirdly, understanding the typical applications of DIC – from fine chemical synthesis to biochemical preparations – helps in specifying the exact grade and quantity needed. Buyers frequently inquire about the price of DIC in relation to different pack sizes, seeking competitive offers from established manufacturers in regions like China, known for its robust chemical manufacturing capabilities.

Identifying a reliable supplier is key to ensuring a stable supply chain. Reputable suppliers will offer competitive pricing, timely delivery, and robust technical support. They often provide product documentation such as Safety Data Sheets (SDS) and Technical Data Sheets (TDS). For bulk purchases, engaging directly with a manufacturer can often yield better pricing and more tailored supply agreements. The global chemical market offers numerous options, but diligence in vetting potential partners is recommended. Seeking recommendations and reviewing supplier credentials can prevent potential issues with product quality or delivery timelines.

In conclusion, N,N'-Diisopropylcarbodiimide is a vital chemical intermediate with diverse and critical applications. Buyers should approach its procurement with a clear understanding of its specifications, typical uses, and the importance of partnering with trustworthy manufacturers and suppliers. By focusing on purity, consistency, and reliable sourcing, procurement professionals can ensure the seamless integration of DIC into their synthesis workflows, ultimately contributing to the successful development and production of high-value chemical products.