N,N'-Diisopropylcarbodiimide: A Versatile Organic Synthesis Reagent for Peptide and Esterification Applications

Discover the advantages of N,N'-Diisopropylcarbodiimide (DIC), a critical reagent for peptide synthesis, esterification, and more. Learn why leading manufacturers and suppliers in China offer this high-purity chemical intermediate for your advanced synthesis needs.

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Key Advantages of Using N,N'-Diisopropylcarbodiimide

Superior Handling and Reactivity

Unlike solid carbodiimides, N,N'-Diisopropylcarbodiimide (DIC) is a colorless to yellowish liquid, simplifying handling and measurement in laboratory and industrial settings. Its high chemical activity ensures efficient condensation reactions.

Simplified Purification Process

The byproduct of DIC-mediated reactions is diisopropylurea, which is readily soluble in common organic solvents, significantly easing post-reaction purification compared to less soluble byproducts from other coupling agents, making it ideal for seeking competitive price for complex syntheses.

Broad Application Spectrum

DIC serves as a vital dehydrating agent for amikacin and glutathione synthesis, and is widely used in the preparation of acid anhydrides, aldehydes, ketones, isocyanates, and critically, in peptide and nucleic acid synthesis. This versatility makes it a go-to chemical intermediate for various industries.

Diverse Applications Driven by DIC's Chemical Properties

Peptide Synthesis

DIC is a premier choice for peptide coupling, offering excellent yields and facilitating the synthesis of complex peptide chains. Researchers frequently buy DIC for its effectiveness in this area.

Esterification Reactions

Efficiently converts carboxylic acids and alcohols into esters under mild conditions. This makes it a preferred reagent for many ester synthesis requirements in fine chemical manufacturing.

Pharmaceutical Intermediates

Plays a crucial role in synthesizing Active Pharmaceutical Ingredients (APIs) and their intermediates, such as amikacin and glutathione, underscoring its importance for the pharmaceutical sector.

Biochemicals and Cosmetics

Its application extends to the synthesis of various biochemicals and ingredients for cosmetics, highlighting its broad utility across different specialized chemical markets.