In the intricate world of organic chemistry, the availability of precise and high-quality building blocks is paramount for successful synthesis. Among these essential compounds is 3-Bromo-5-methylbenzonitrile (CAS 124289-21-0). This benzonitrile derivative has garnered significant attention from researchers and industrial chemists alike due to its unique structural features and versatile applications.

Understanding 3-Bromo-5-methylbenzonitrile

3-Bromo-5-methylbenzonitrile, with the molecular formula C8H6BrN and a molecular weight of 196.04, is characterized by its bromine and nitrile functional groups attached to a methyl-substituted benzene ring. Typically appearing as a white to off-white solid, it possesses a melting point range of 57-58.5℃ and a boiling point of approximately 256.1±20.0℃. These physical properties, combined with its chemical reactivity, make it a sought-after intermediate in various synthetic pathways.

Key Applications in Synthesis

The primary utility of 3-Bromo-5-methylbenzonitrile lies in its ability to facilitate the synthesis of arenes with high steric regiocontrol. This means that chemists can use it to precisely control where new chemical groups are attached to a molecule, a critical factor in designing complex organic structures. Its applications span several fields:

  • Pharmaceutical Intermediates: The compound serves as a valuable precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs). Its specific arrangement of functional groups allows for the introduction of desired functionalities into drug candidates, aiding in the development of new therapeutics.
  • Agrochemicals: Similar to pharmaceuticals, its structural features can be leveraged in the creation of novel agrochemical compounds, contributing to advancements in crop protection and yield enhancement.
  • Material Science: Researchers in material science might utilize 3-Bromo-5-methylbenzonitrile for developing advanced materials with specific electronic or optical properties, where precise aromatic structures are key.
  • General Organic Synthesis: Beyond specialized fields, it's a useful reagent for academic and industrial laboratories engaged in fundamental organic chemistry research, exploring new reaction methodologies and synthesizing novel organic compounds.

Sourcing Reliability: Manufacturer and Supplier Insights

For procurement managers and research scientists, ensuring a reliable supply of high-quality chemicals is crucial. When looking to buy 3-Bromo-5-methylbenzonitrile, partnering with reputable manufacturers and suppliers is essential. Leading companies in China specialize in producing this intermediate, often offering competitive pricing and bulk quantities to meet diverse project demands. When sourcing, look for suppliers who provide detailed specifications, Certificates of Analysis (CoA), and can guarantee consistent product purity. Many suppliers offer free samples, allowing you to verify quality before committing to larger orders.

Why Choose a Chinese Supplier?

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates like 3-Bromo-5-methylbenzonitrile. Manufacturers in this region often benefit from economies of scale, advanced production technologies, and robust supply chain networks, enabling them to provide high-quality products at competitive prices. For businesses seeking cost-effective procurement solutions without compromising on quality, exploring Chinese manufacturers and suppliers for 3-Bromo-5-methylbenzonitrile is a strategic move. Remember to always verify the supplier's credentials and product quality assurance processes.

In conclusion, 3-Bromo-5-methylbenzonitrile is an indispensable chemical building block. Its specific reactivity and structural attributes make it vital for numerous advanced synthesis projects. By understanding its properties and strategically sourcing from reliable manufacturers, researchers and businesses can effectively leverage this compound to drive innovation in pharmaceuticals, agrochemicals, and material science.