The Synergy of Bromine and Trifluoromethyl Groups: Applications of 2-Bromo-4-(trifluoromethyl)benzonitrile
The unique properties conferred by the combined presence of bromine and trifluoromethyl groups make certain chemical intermediates exceptionally valuable in organic synthesis. 2-Bromo-4-(trifluoromethyl)benzonitrile (CAS: 35764-15-9) is a prime example, offering a versatile platform for constructing complex molecules. NINGBO INNO PHARMCHEM CO.,LTD., a leading manufacturer in China, supplies this critical intermediate, enabling advancements across various scientific disciplines.
The trifluoromethyl (–CF3) group is a powerhouse in molecular design. Its high electronegativity and lipophilicity can significantly alter a molecule's pharmacokinetic properties, stability, and binding characteristics. When paired with a bromine atom, as in 2-Bromo-4-(trifluoromethyl)benzonitrile, the molecule gains enhanced reactivity. The bromine atom is an excellent leaving group, facilitating a wide range of metal-catalyzed cross-coupling reactions like Suzuki, Heck, and Sonogashira couplings. These reactions are fundamental for building carbon-carbon bonds and creating intricate molecular architectures essential for pharmaceuticals, agrochemicals, and electronic materials.
For instance, in pharmaceutical research, the ability to readily functionalize this benzonitrile derivative allows for the synthesis of novel drug candidates with improved efficacy and bioavailability. Similarly, in agrochemical development, the incorporation of the trifluoromethyl moiety can lead to more potent and persistent active ingredients. The availability of this intermediate from a reliable supplier ensures that chemists can confidently integrate it into their synthetic strategies.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity intermediates, including 2-Bromo-4-(trifluoromethyl)benzonitrile, to support cutting-edge research and development. The competitive price and consistent quality offered by this China-based manufacturer make it an ideal choice for companies seeking to optimize their chemical sourcing. By understanding the synergistic power of the bromine and trifluoromethyl groups in this benzonitrile, researchers can unlock new possibilities in molecular design and create innovative products.
The trifluoromethyl (–CF3) group is a powerhouse in molecular design. Its high electronegativity and lipophilicity can significantly alter a molecule's pharmacokinetic properties, stability, and binding characteristics. When paired with a bromine atom, as in 2-Bromo-4-(trifluoromethyl)benzonitrile, the molecule gains enhanced reactivity. The bromine atom is an excellent leaving group, facilitating a wide range of metal-catalyzed cross-coupling reactions like Suzuki, Heck, and Sonogashira couplings. These reactions are fundamental for building carbon-carbon bonds and creating intricate molecular architectures essential for pharmaceuticals, agrochemicals, and electronic materials.
For instance, in pharmaceutical research, the ability to readily functionalize this benzonitrile derivative allows for the synthesis of novel drug candidates with improved efficacy and bioavailability. Similarly, in agrochemical development, the incorporation of the trifluoromethyl moiety can lead to more potent and persistent active ingredients. The availability of this intermediate from a reliable supplier ensures that chemists can confidently integrate it into their synthetic strategies.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity intermediates, including 2-Bromo-4-(trifluoromethyl)benzonitrile, to support cutting-edge research and development. The competitive price and consistent quality offered by this China-based manufacturer make it an ideal choice for companies seeking to optimize their chemical sourcing. By understanding the synergistic power of the bromine and trifluoromethyl groups in this benzonitrile, researchers can unlock new possibilities in molecular design and create innovative products.
Perspectives & Insights
Alpha Spark Labs
“is committed to providing high-purity intermediates, including 2-Bromo-4-(trifluoromethyl)benzonitrile, to support cutting-edge research and development.”
Future Pioneer 88
“The competitive price and consistent quality offered by this China-based manufacturer make it an ideal choice for companies seeking to optimize their chemical sourcing.”
Core Explorer Pro
“By understanding the synergistic power of the bromine and trifluoromethyl groups in this benzonitrile, researchers can unlock new possibilities in molecular design and create innovative products.”