For synthetic chemists and procurement managers in the pharmaceutical and fine chemical industries, understanding the technical specifications and proper handling of key reagents is paramount. 2-Chlorotrityl Chloride (2-CTC) resin is a critical solid support in solid-phase synthesis, and its optimal use hinges on a thorough understanding of its properties. NINGBO INNO PHARMCHEM CO.,LTD., as a leading chemical manufacturer and supplier, aims to provide comprehensive technical insights into the materials we offer.

Chemical Structure and Physical Properties

2-CTC resin is typically a cross-linked polystyrene matrix functionalized with the 2-chlorotrityl chloride moiety. Its physical appearance is often described as grey-white to yellow or brown beads. Key characteristics include its high acid lability, which is precisely what enables the mild cleavage of attached molecules. The polymer backbone is usually cross-linked with divinylbenzene (DVB), typically at 1% or 2%, which influences its swelling properties in various solvents. Swelling is crucial for reagent diffusion into the resin beads, impacting reaction kinetics.

Advantages and Mechanisms of Action

The primary advantage of 2-CTC resin is its capacity for very mild acidic cleavage. Unlike other resins that require strong acids, 2-CTC resin can be cleaved using dilute solutions of TFA (1-5%) in DCM. This gentleness is vital for protecting acid-sensitive groups present in the synthesized molecules. For example, in peptide synthesis, it preserves Boc and tBu protecting groups, which is essential for preparing protected peptide fragments. Researchers often look to buy 2-chlorotrityl chloride resin specifically for this mild cleavage capability.

Additionally, the steric bulk of the trityl group minimizes unwanted side reactions such as diketopiperazine (DKP) formation and racemization, particularly at the C-terminus of peptides. This leads to cleaner synthesis outcomes and higher purity products, a significant benefit for anyone looking to purchase high-quality peptide synthesis reagents. The resin also offers good loading capacities, contributing to efficient synthesis workflows.

Handling and Storage Recommendations

To maintain the integrity and reactivity of 2-CTC resin, proper handling and storage are essential. The resin should be stored in a cool, dry place, preferably under an inert atmosphere, to prevent degradation from moisture and air. Exposure to even trace amounts of acid or prolonged contact with protic solvents can lead to premature cleavage. When handling, it is important to use anhydrous solvents and reagents. Pre-swelling the resin in a suitable solvent, such as DCM or DMF, before commencing a reaction is a standard practice that ensures optimal reactivity.

Comparison with Other Resins

  • vs. Wang Resin: Wang resin requires stronger acidic cleavage conditions (50-95% TFA), making 2-CTC resin preferable for acid-sensitive compounds.
  • vs. Merrifield Resin: Merrifield resin is more acid-stable, requiring very strong acids for cleavage, limiting its use for delicate molecules.
  • vs. Trityl Resin: Standard trityl resin is generally more acid-labile than 2-CTC resin, potentially leading to premature cleavage during synthesis.

Procuring 2-CTC Resin from NINGBO INNO PHARMCHEM CO.,LTD.

NINGBO INNO PHARMCHEM CO.,LTD. is a reliable 2-chlorotrityl chloride resin supplier, offering various specifications to meet diverse synthesis needs. We provide competitive 2-chlorotrityl chloride resin prices and ensure consistent product quality. If you are looking to purchase 2-chlorotrityl chloride resin, our team is ready to assist you with your inquiries and bulk orders.

Understanding the technical nuances of 2-CTC resin empowers chemists to maximize its benefits. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing the high-quality materials and support necessary for successful synthetic endeavors.