Tetradecanedioic acid (CAS 821-38-5), a C14 long-chain dicarboxylic acid, stands out as a highly versatile intermediate in the field of organic synthesis. Its dual carboxylic acid functionality and extended hydrophobic tail make it a valuable building block for a wide range of chemical transformations, serving industries from pharmaceuticals to specialty chemicals.

Understanding its Chemical Reactivity

The two terminal carboxylic acid groups (-COOH) are the primary reactive sites on tetradecanedioic acid. These groups readily undergo typical carboxylic acid reactions, allowing for the synthesis of various derivatives:

  • Esterification: Reaction with alcohols in the presence of an acid catalyst yields diesters. These esters can function as plasticizers, lubricants, or intermediates for further synthesis.
  • Amidation: Reaction with amines forms diamides, which are important in the synthesis of polyamides and other nitrogen-containing compounds.
  • Acid Halide Formation: Treatment with reagents like thionyl chloride (SOCl₂) converts the carboxylic acid groups into highly reactive acid chlorides, which are excellent acylating agents.
  • Anhydride Formation: Dehydration can lead to the formation of cyclic or linear anhydrides, which are also reactive intermediates.

Key Applications in Organic Synthesis

As an organic synthesis intermediate, tetradecanedioic acid is sought after for several critical applications:

  • Pharmaceutical Intermediates: Its structure can be incorporated into active pharmaceutical ingredients (APIs) or used in the synthesis of prodrugs or drug delivery systems. The long aliphatic chain can influence lipophilicity and membrane permeability. For researchers and manufacturers needing high-purity intermediates, sourcing tetradecanedioic acid from reputable manufacturers is essential.
  • Fine Chemical Manufacturing: It serves as a precursor for surfactants, lubricants, and corrosion inhibitors, where its long hydrocarbon chain contributes to desired surface-active or protective properties.
  • Specialty Chemicals: In the development of niche chemicals, tetradecanedioic acid provides a stable C14 backbone for complex molecular structures.

Procurement for Synthesis Projects

When planning organic synthesis projects requiring tetradecanedioic acid (CAS 821-38-5), it is vital to partner with reliable suppliers. Key considerations for procurement include:

  • Purity: Ensure the tetradecanedioic acid meets high purity standards (e.g., >97%).
  • Availability: Secure a consistent supply from manufacturers experienced in bulk production.
  • Pricing: Obtain competitive quotes from established suppliers, particularly those based in China, for cost-effective project management.

In conclusion, tetradecanedioic acid is an indispensable tool in the synthetic chemist's arsenal. Its reactivity and structural attributes enable the creation of a vast array of complex molecules, underscoring its importance as a fine chemical intermediate.