In the complex world of chemical manufacturing, the availability of reliable and versatile intermediates is key to innovation and efficient production. 3-Chloro-4-fluorotoluene, identified by CAS number 1513-25-3, is one such compound, offering unique chemical properties that make it invaluable for a range of industrial applications, particularly in the pharmaceutical and agrochemical sectors. This article highlights its attributes and its significance for global manufacturing, including sourcing from China.

Core Chemical Properties of 3-Chloro-4-fluorotoluene

3-Chloro-4-fluorotoluene is chemically defined by its formula C7H6ClF, with a molecular weight of 144.57400. It is typically supplied as a colorless to light yellow transparent liquid. Its physical characteristics are important for safe handling and effective use: it has a boiling point of 167°C and a flash point of 45.4°C, categorizing it as a flammable liquid. The density is 1.358 g/cm³. The presence of both chlorine and fluorine atoms on the aromatic ring provides distinct reactivity, allowing for specific transformations that are crucial in synthetic organic chemistry. This makes it a preferred intermediate for complex molecular designs.

Crucial Role in Pharmaceutical Synthesis

The pharmaceutical industry extensively utilizes 3-Chloro-4-fluorotoluene as a building block for the synthesis of Active Pharmaceutical Ingredients (APIs). Its halogen substituents offer strategic points for chemical reactions, enabling the precise construction of drug molecules with desired pharmacological activities. Companies specializing in pharmaceutical intermediates often source this compound to develop innovative therapeutics. The consistent purity (≥98%) and low water content (≤0.5%) ensured by manufacturers, particularly those in China, guarantee the reliability needed for drug development and production. This ensures that the synthesized APIs meet stringent quality standards.

Applications in Agrochemicals

In the agrochemical sector, 3-Chloro-4-fluorotoluene is a key intermediate for producing advanced crop protection agents. It serves as a foundation for synthesizing herbicides, pesticides, and fungicides that are essential for modern agriculture. The specific chemical structure it helps create can lead to more targeted and effective pest control solutions, contributing to increased crop yields and food security. The availability of this intermediate from efficient manufacturing bases in China supports the global supply chain for these vital agricultural inputs, ensuring farmers have access to effective tools.

Considerations for Procurement and Use

When sourcing 3-Chloro-4-fluorotoluene, it is essential to partner with suppliers who can guarantee product quality and consistent supply. Packaging in 25kg drums is standard for industrial use. Due to its flammable nature, proper storage in cool, dry, and well-ventilated areas, away from potential ignition sources, is crucial. Adherence to safety protocols ensures the compound's integrity and safe handling throughout the supply chain.

In conclusion, 3-Chloro-4-fluorotoluene (CAS 1513-25-3) is a highly valuable intermediate, underpinning significant advancements in pharmaceuticals and agrochemicals. Its distinct chemical properties and the robust manufacturing capabilities found in China make it a critical component for industries worldwide.