The landscape of chemical synthesis is constantly evolving, driven by the need for advanced materials and efficient production processes. Within this domain, specific chemical intermediates play a crucial role, and 3-Chloro-4-fluorotoluene, identified by CAS number 1513-25-3, stands out for its versatility and wide-ranging applications. This article provides an in-depth look at its characteristics and importance, especially from the perspective of sourcing from China.

Understanding the Compound: Properties and Characteristics

3-Chloro-4-fluorotoluene is a halogenated aromatic compound with the chemical formula C7H6ClF and a molecular weight of 144.57400. It typically presents as a colorless to light yellow transparent liquid. Key physical parameters include a boiling point of 167°C and a flash point of 45.4°C, classifying it as a flammable substance. Its density is 1.358 g/cm³. The unique molecular structure, featuring chlorine and fluorine substituents on a toluene ring, imbues it with specific reactivity that is highly valued in synthetic chemistry. These properties make it an effective intermediate for creating more complex molecules with tailored characteristics.

Applications in Organic Synthesis

The primary application of 3-Chloro-4-fluorotoluene lies in its utility as an organic intermediate. Its structure is particularly useful for building complex carbon frameworks and introducing specific functionalities into target molecules. This makes it a vital component in multi-step synthesis pathways across various chemical industries. Its role as an intermediate for pharmaceutical synthesis is significant, contributing to the development of new drugs and therapies. Similarly, in the agrochemical sector, it serves as a precursor for crafting effective crop protection agents, such as herbicides and pesticides, thereby supporting agricultural productivity and food security.

Sourcing and Quality Assurance

For industries relying on high-purity chemical inputs, sourcing 3-Chloro-4-fluorotoluene from reputable suppliers is paramount. Manufacturers in China are increasingly recognized for their capability to produce this intermediate with high purity levels, typically ≥98%, and low water content, usually ≤0.5%. These specifications are crucial for ensuring reliable and reproducible results in demanding synthetic processes. Packaging, often in 25kg drums, is designed to maintain product integrity during transport and storage. Proper handling, considering its flammable nature, is essential, involving storage in cool, dry, and well-ventilated environments.

Why This Intermediate Matters

The strategic importance of 3-Chloro-4-fluorotoluene stems from its ability to bridge simple starting materials to complex end-products in both pharmaceuticals and agrochemicals. Its halogenated nature allows for diverse chemical reactions, including nucleophilic substitution and metal-catalyzed cross-coupling, expanding its synthetic utility. As the global demand for advanced chemical products grows, intermediates like 3-Chloro-4-fluorotoluene, readily available from efficient manufacturing bases like China, become increasingly critical for driving innovation and meeting market needs.

In summary, 3-Chloro-4-fluorotoluene (CAS 1513-25-3) is a cornerstone intermediate for organic synthesis, with critical applications in the pharmaceutical and agrochemical industries. Its properties, coupled with the manufacturing capabilities available in China, position it as a key chemical for future advancements.