For chemists and procurement specialists in the specialty chemical and pharmaceutical sectors, a thorough understanding of a compound's properties is essential for effective utilization. This article provides a comprehensive overview of 2,6-Dibromo-4-methylpyridine (CAS 73112-16-0), covering its key physical and chemical characteristics and its critical role in various synthetic processes.

Chemical Identity and Structure

2,6-Dibromo-4-methylpyridine, also known by synonyms such as 2,6-dibromo-4-picoline, is a pyridine derivative with the molecular formula C6H5Br2N and a molecular weight of approximately 250.92 g/mol. Its structure features a pyridine ring with bromine atoms substituted at the 2 and 6 positions and a methyl group at the 4 position. This specific arrangement of substituents dictates its reactivity and applications in organic chemistry.

Physical and Chemical Properties

The compound typically appears as a white crystalline powder. Its melting point is generally reported in the range of 77-79°C, which is a crucial parameter for identification and quality control. The high purity, typically 97% or greater, ensures its reliability in sensitive chemical reactions. While detailed solubility data may vary, it is generally soluble in common organic solvents. The presence of two bromine atoms on the electron-deficient pyridine ring makes these positions susceptible to nucleophilic substitution and metal-catalyzed cross-coupling reactions, forming the basis of its synthetic utility.

Applications and Synthetic Utility

The primary application of 2,6-dibromo-4-methylpyridine is as a versatile intermediate in organic synthesis. Its reactive bromine atoms allow chemists to introduce a wide range of functional groups through various coupling reactions, such as:

  • Suzuki Coupling: For forming carbon-carbon bonds with boronic acids.
  • Stille Coupling: For coupling with organotin reagents.
  • Buchwald-Hartwig Amination: For introducing amine functionalities.

These reactions are fundamental in constructing complex molecular scaffolds, particularly in the development of new pharmaceuticals and agrochemicals. Researchers seeking to buy 2,6-dibromo-4-methylpyridine often rely on its predictable reactivity for building targeted molecular structures.

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