Iodobenzene, identified by its CAS number 591-50-4, is a chemical compound of considerable importance in the field of organic chemistry. This aryl halide, with the molecular formula C6H5I, is characterized by its colorless to pale yellow liquid appearance and a molecular weight of 204.01 g/mol. Its significance stems from its accessible synthesis routes and its superior reactivity compared to other halobenzenes, making it a favored reagent for various synthetic transformations. NINGBO INNO PHARMCHEM CO.,LTD. leverages these characteristics to produce high-quality chemical intermediates.

The synthesis of Iodobenzene typically involves the diazotization of aniline, followed by reaction with potassium iodide. In this process, aniline is first treated with sodium nitrite and an acid (like hydrochloric acid) to form a diazonium salt. This intermediate is then reacted with potassium iodide, which displaces the diazonium group, releasing nitrogen gas and yielding Iodobenzene. Another method involves the direct iodination of benzene using iodine and an oxidizing agent such as nitric acid. Understanding these iodobenzene synthesis pathways is crucial for efficient production and supply chain management.

The chemical reactivity of Iodobenzene is a defining feature that sets it apart. The carbon-iodine (C-I) bond is considerably weaker and more polarized than the C-Cl or C-Br bonds found in chlorobenzene and bromobenzene, respectively. This increased reactivity makes Iodobenzene an excellent substrate for nucleophilic substitution reactions and, more importantly, for organometallic reactions. It readily reacts with magnesium to form phenylmagnesium iodide, a Grignard reagent that is a powerful tool for carbon-carbon bond formation in iodobenzene organic synthesis. When seeking to buy Iodobenzene, focusing on its purity ensures optimal reactivity.

Furthermore, Iodobenzene is a prime reactant in many transition-metal-catalyzed cross-coupling reactions. Its participation in reactions like the Sonogashira coupling (with terminal alkynes) and the Heck reaction (with alkenes) is highly efficient. These reactions are foundational for constructing complex organic molecules, including pharmaceuticals and advanced materials. The ease with which Iodobenzene undergoes oxidative addition with palladium catalysts makes it a preferred choice over less reactive aryl halides in many synthetic schemes. This characteristic is vital for achieving high yields in iodobenzene Sonogashira coupling and iodobenzene Heck reaction protocols.

The utility of Iodobenzene extends to its role as a standard in refractive index measurements. Its stable optical properties allow it to serve as a reliable reference material, ensuring accuracy in scientific instruments and industrial quality control. Proper identification of iodobenzene CAS 591-50-4 is key to sourcing the correct material for these precise applications.

Safety is a key consideration when working with Iodobenzene. As a photosensitive compound, it should be stored away from light. Its handling requires adherence to standard laboratory safety practices, including the use of personal protective equipment. Knowledge of iodobenzene safety handling procedures is indispensable for all users.

In essence, Iodobenzene (CAS 591-50-4) is a chemical workhorse, enabling complex syntheses through its inherent reactivity. Its synthesis routes and participation in key cross-coupling reactions make it a vital compound for NINGBO INNO PHARMCHEM CO.,LTD. and the broader chemical industry, facilitating innovation across multiple sectors.