Iodobenzene, a phenyl iodide with the chemical formula C6H5I and CAS number 591-50-4, is a fundamental organic compound celebrated for its distinct properties and extensive applications. As a colorless to pale yellow liquid, it possesses a molecular weight of 204.01 g/mol and exhibits characteristics that make it invaluable in numerous chemical processes. This article aims to provide a comprehensive understanding of Iodobenzene's properties, its role as a refractive index standard, and its critical functions within organic synthesis, particularly for NINGBO INNO PHARMCHEM CO.,LTD.

The physical and chemical properties of Iodobenzene are central to its utility. It is a liquid at room temperature, with a boiling point of approximately 188°C and a melting point around -29°C. One of its most significant applications is its use as a standard refractive index liquid. The consistency and well-defined optical properties of Iodobenzene make it an excellent calibration material for instruments used in spectroscopy and optical analysis. Accurate refractive index measurements are paramount in quality control and research, ensuring the integrity of data and the reliability of materials.

In the realm of iodobenzene organic synthesis, the compound's reactivity is highly prized. The carbon-iodine bond is labile, allowing Iodobenzene to participate readily in a variety of transformations. It is frequently used to prepare phenylmagnesium iodide, a Grignard reagent vital for forming new carbon-carbon bonds. This capability is extensively leveraged in the synthesis of complex molecules, including those with applications in the pharmaceutical industry. When searching for iodobenzene supplier, focus on those providing high purity for optimal synthetic outcomes.

Moreover, Iodobenzene is a preferred substrate in several palladium-catalyzed cross-coupling reactions. The Sonogashira coupling, for instance, enables the formation of carbon-carbon triple bonds by reacting an aryl halide with a terminal alkyne. Similarly, the Heck reaction couples aryl halides with alkenes. Iodobenzene's high reactivity in these reactions, often referred to as iodobenzene Sonogashira coupling and iodobenzene Heck reaction, means that chemists can achieve efficient syntheses of important compounds like stilbenes and biaryls, which are building blocks for many advanced materials and drugs. This makes understanding iodobenzene properties crucial for synthetic chemists.

The demand for Iodobenzene is substantial in sectors requiring precise chemical synthesis. As a vital iodobenzene pharmaceutical intermediate, it contributes to the manufacturing of various therapeutic agents. Its structure can be incorporated into drug molecules, aiding in their pharmacological activity. The compound is also utilized in the agrochemical industry for the synthesis of pesticides, highlighting its broad industrial impact. For procurement, understanding the typical price of iodobenzene and ensuring a reliable supply chain is important for manufacturers.

When considering the handling and storage of Iodobenzene, its photosensitive nature must be addressed. Exposure to light can lead to decomposition, often resulting in a yellowish discoloration. Therefore, it should be stored in tightly sealed, dark containers in a cool, well-ventilated environment. Strict adherence to iodobenzene safety handling practices is necessary to prevent exposure and ensure efficient use. Its classification and hazard statements are important references for safe laboratory operations.

In summary, Iodobenzene (CAS 591-50-4) is a compound of immense value, bridging the gap between fundamental chemical principles and practical industrial applications. Its unique optical properties as a refractive index standard and its catalytic role in sophisticated organic synthesis pathways make it an indispensable tool for NINGBO INNO PHARMCHEM CO.,LTD. and the broader chemical community.