In the specialized domain of fine chemical manufacturing, the selection of appropriate starting materials and intermediates is critical for the successful synthesis of high-value compounds. 2-Bromoacetophenone (CAS 70-11-1), also known as Phenacyl bromide, has established itself as a cornerstone intermediate in this industry due to its versatile reactivity and well-defined chemical properties.

The chemical structure of 2-Bromoacetophenone, featuring a reactive bromine atom adjacent to a carbonyl group on an aromatic ring, provides a potent combination of features for organic synthesis. This structure allows it to function as a key electrophilic reagent, readily participating in nucleophilic substitution reactions. Furthermore, its acylating capabilities enable the straightforward introduction of the phenacyl moiety into a wide range of organic molecules. These characteristics are fundamental for constructing complex molecular architectures required in the fine chemical sector.

The fine chemical industry relies on intermediates like 2-Bromoacetophenone for the production of specialty chemicals, custom synthesis projects, and advanced materials. Its application extends to areas such as the synthesis of dyes, fragrances, and, notably, pharmaceutical intermediates. For instance, its use in the production of Ubenimex underscores its importance in the pharmaceutical supply chain, where high purity and consistent quality are non-negotiable. Manufacturers typically ensure that their 2-Bromoacetophenone meets stringent specifications, including purity levels often exceeding 99%, to guarantee reliable outcomes in subsequent synthetic steps.

The manufacturing process for 2-Bromoacetophenone commonly involves the selective bromination of acetophenone. This process is optimized to yield a product with minimal impurities, ensuring its suitability for demanding applications. The chemical’s physical properties, such as its appearance as a white crystalline powder and its melting point of approximately 48-51°C, are important for handling and processing. Furthermore, understanding its reactivity and stability is crucial for process development, allowing for the design of efficient and safe manufacturing protocols.

The consistent demand for 2-Bromoacetophenone in fine chemical manufacturing highlights its indispensable role. Its versatility as a building block, coupled with the availability of reliable suppliers who can deliver high-quality material, makes it a preferred choice for synthetic chemists. As the demand for specialized and complex organic molecules continues to grow across various industries, the importance of intermediates like 2-Bromoacetophenone is only set to increase, driving further innovation in chemical synthesis and manufacturing.