Iodobenzene, identified by CAS number 591-50-4, is a foundational aryl halide whose chemical properties make it exceptionally valuable in modern organic synthesis, particularly in catalytic transformations. As a colorless to pale yellow liquid with the molecular formula C6H5I, its molecular weight of 204.01 g/mol is accompanied by a distinct reactivity profile that sets it apart from other halobenzenes. This enhanced reactivity, coupled with its strategic role in key reactions, makes Iodobenzene a cornerstone for chemical manufacturers like NINGBO INNO PHARMCHEM CO.,LTD.

The exceptional reactivity of Iodobenzene is primarily attributed to the relatively weak bond strength of the carbon-iodine linkage. This characteristic allows Iodobenzene to readily undergo oxidative addition with transition metal catalysts, such as palladium complexes, which are central to many catalytic coupling reactions. Compared to bromobenzene and chlorobenzene, Iodobenzene typically reacts faster and under milder conditions, making it a preferred substrate for many complex syntheses. This is why understanding iodobenzene properties is crucial for synthetic chemists.

Among the most significant applications of Iodobenzene's reactivity are its roles in the Sonogashira coupling and the Heck reaction. The Sonogashira coupling, a powerful method for forming carbon-carbon triple bonds, involves the palladium- and copper-catalyzed reaction between a terminal alkyne and an aryl halide. Iodobenzene is an excellent partner in this reaction, enabling the efficient synthesis of various alkynylarenes, which are prevalent in pharmaceuticals, advanced materials, and natural products. The efficiency of iodobenzene Sonogashira coupling is a testament to its suitability for demanding synthetic tasks.

Similarly, the Heck reaction, which couples aryl halides with alkenes, finds Iodobenzene to be a highly effective substrate. This palladium-catalyzed process is vital for creating substituted alkenes, including stilbenes and other olefinic compounds. The ability of Iodobenzene to participate readily in the Heck reaction allows for the synthesis of diverse conjugated systems, which are important in areas such as organic electronics and medicinal chemistry. The ease of performing the iodobenzene Heck reaction makes it a go-to choice for many researchers and industrial chemists.

The application of Iodobenzene in these catalytic transformations is not limited to academic research; it is fundamental to industrial production. As a key iodobenzene intermediate, it facilitates the scale-up of complex molecules. NINGBO INNO PHARMCHEM CO.,LTD. utilizes Iodobenzene to produce a range of fine chemicals and pharmaceutical precursors, relying on its predictable reactivity. When sourcing Iodobenzene, ensuring a high iodobenzene purity is critical for consistent catalytic performance.

The preparation and handling of Iodobenzene also involve specific considerations. While it can be synthesized through methods like aniline diazotization, its photosensitive nature requires careful storage to maintain its quality. Adhering to proper iodobenzene safety handling protocols is paramount for safe and effective use in laboratory and industrial settings. The accurate identification of the compound via its iodobenzene CAS 591-50-4 number is also essential for procurement and regulatory compliance.

In conclusion, Iodobenzene (CAS 591-50-4) stands out due to its enhanced reactivity, particularly in catalytic cross-coupling reactions like the Sonogashira and Heck couplings. This makes it an indispensable reagent for NINGBO INNO PHARMCHEM CO.,LTD. and the broader chemical industry, enabling the efficient synthesis of complex molecules that drive innovation in medicine, materials science, and beyond.