In the intricate world of organic chemistry, certain molecules stand out for their versatility and importance as building blocks. 2-Fluoro-5-nitroanisole, identified by its CAS number 454-16-0, is one such compound. It's a critical intermediate that facilitates the synthesis of a wide array of complex organic molecules, making it highly sought after in various industrial and research applications. Understanding its properties and applications is key for chemists aiming to optimize their synthetic strategies and explore new chemical frontiers.

What is 2-Fluoro-5-nitroanisole?

2-Fluoro-5-nitroanisole, also known by synonyms such as 4-Fluoro-3-methoxynitrobenzene and 1-Fluoro-2-methoxy-4-nitrobenzene, is a fluorinated aromatic compound. Its molecular formula is C7H6FNO3, with a molecular weight of 171.13 g/mol. Typically, it presents as a light yellow solid, with a melting point range of 66-71°C. Its structure, featuring both a fluorine atom and a nitro group attached to an anisole ring, endows it with unique reactivity, making it an excellent starting material for various chemical transformations.

Synthesis and Purity Considerations

The preparation of 2-Fluoro-5-nitroanisole often involves the methylation of 2-fluoro-5-nitrophenol using reagents like iodomethane in the presence of a base such as potassium carbonate in a solvent like N,N-dimethylformamide (DMF). The purification process is crucial to achieve the high purity levels, often exceeding 99.5%, which are required for its applications in sensitive synthesis pathways. For those looking to buy 2-Fluoro-5-nitroanisole, sourcing from reputable manufacturers who guarantee purity and consistency is paramount.

Key Applications in Chemical Synthesis

The utility of 2-Fluoro-5-nitroanisole extends across several sectors:

  • Pharmaceutical Industry: It serves as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its functional groups can be modified to introduce specific properties into drug molecules, aiding in the development of novel therapeutics. The accurate price of this intermediate can significantly impact drug development costs.
  • Agrochemicals: In the agrochemical sector, this compound is used to create advanced pesticides, herbicides, and other crop protection agents. Its structure can be tailored to enhance efficacy and reduce environmental impact.
  • Material Science and Specialty Chemicals: The unique electronic and chemical properties imparted by the fluorine and nitro groups make it valuable in the development of specialty materials, dyes, and electronic chemicals.
  • Research and Development: For academic and industrial researchers, 2-Fluoro-5-nitroanisole is an indispensable tool for exploring new reaction mechanisms, synthesizing complex organic structures, and discovering novel compounds. Inquiring about the 2-Fluoro-5-nitroanisole price is a common step for R&D projects.

Sourcing High-Quality Intermediates

When seeking to purchase 2-Fluoro-5-nitroanisole, particularly from suppliers in China, it is important to prioritize quality and reliability. Understanding the CAS 454-16-0 properties and comparing 4-Fluoro-3-methoxynitrobenzene characteristics with your specific needs will help in selecting the right supplier. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer and supplier focused on providing high-quality chemical intermediates, ensuring that your scientific endeavors are supported by dependable materials.