Understanding 4-Bromo-2-fluorobenzoyl Chloride: Properties and Uses in Industry
In the realm of fine chemicals and organic synthesis, understanding the properties and applications of key intermediates is paramount. 4-Bromo-2-fluorobenzoyl Chloride, identified by its CAS number 151982-51-3, is a significant compound that serves as a versatile building block across multiple industries. This article delves into its essential characteristics, typical synthesis routes, and its vital role in driving innovation in pharmaceuticals, agrochemicals, and beyond.
The fundamental properties of 4-Bromo-2-fluorobenzoyl Chloride are crucial for its effective handling and application. Typically appearing as a white to pale yellow liquid or fused solid, it possesses a distinct melting point of approximately 24-24.5°C. Its molecular formula is C7H3BrClFO, with a molecular weight of about 237.45 g/mol. The presence of the acyl chloride functional group makes it highly reactive, particularly towards nucleophiles, and sensitive to moisture, necessitating anhydrous storage conditions. These attributes are critical considerations for chemists when procuring or utilizing this chemical intermediate.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride generally involves the conversion of 4-bromo-2-fluorobenzoic acid. This transformation is commonly achieved by reacting the carboxylic acid with chlorinating agents such as thionyl chloride (SOCl2) or oxalyl chloride (COCl2). Often, a catalyst like dimethylformamide (DMF) is used to facilitate the reaction, which proceeds under anhydrous conditions. For chemical manufacturers, optimizing these 4-bromo-2-fluorobenzoyl chloride synthesis pathways is key to ensuring high purity and consistent quality. NINGBO INNO PHARMCHEM CO.,LTD., as a producer in China, is dedicated to upholding stringent quality control measures.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is characterized by its acyl chloride moiety, which readily engages in nucleophilic acyl substitution reactions. This allows for the facile formation of amides, esters, and thioesters upon reaction with amines, alcohols, and thiols, respectively. These reactions are foundational in constructing complex organic molecules. Additionally, the compound can participate in Friedel-Crafts acylation, a process that attaches the 4-bromo-2-fluorobenzoyl group to aromatic rings. These versatile reaction capabilities make it an invaluable tool in organic synthesis. Sourcing reliable materials, such as from NINGBO INNO PHARMCHEM CO.,LTD., ensures the successful implementation of these chemical processes.
The industrial applications of 4-Bromo-2-fluorobenzoyl Chloride are extensive and significant. In the pharmaceutical industry, it serves as a critical intermediate for the synthesis of various active pharmaceutical ingredients (APIs), contributing to the development of new therapeutic agents. Its unique structure can influence the biological activity and pharmacokinetic profiles of the final drug molecules. In the agrochemical sector, it is employed in the production of pesticides and herbicides, playing a role in modern agricultural practices. Furthermore, its utility extends to material science, where it can be used in the synthesis of specialized polymers and advanced materials. The continuous demand for high-quality 4-bromo-2-fluorobenzoyl chloride reflects its indispensable contribution to various fields of chemical innovation. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted supplier, committed to providing this essential intermediate.
The fundamental properties of 4-Bromo-2-fluorobenzoyl Chloride are crucial for its effective handling and application. Typically appearing as a white to pale yellow liquid or fused solid, it possesses a distinct melting point of approximately 24-24.5°C. Its molecular formula is C7H3BrClFO, with a molecular weight of about 237.45 g/mol. The presence of the acyl chloride functional group makes it highly reactive, particularly towards nucleophiles, and sensitive to moisture, necessitating anhydrous storage conditions. These attributes are critical considerations for chemists when procuring or utilizing this chemical intermediate.
The synthesis of 4-Bromo-2-fluorobenzoyl Chloride generally involves the conversion of 4-bromo-2-fluorobenzoic acid. This transformation is commonly achieved by reacting the carboxylic acid with chlorinating agents such as thionyl chloride (SOCl2) or oxalyl chloride (COCl2). Often, a catalyst like dimethylformamide (DMF) is used to facilitate the reaction, which proceeds under anhydrous conditions. For chemical manufacturers, optimizing these 4-bromo-2-fluorobenzoyl chloride synthesis pathways is key to ensuring high purity and consistent quality. NINGBO INNO PHARMCHEM CO.,LTD., as a producer in China, is dedicated to upholding stringent quality control measures.
The reactivity of 4-Bromo-2-fluorobenzoyl Chloride is characterized by its acyl chloride moiety, which readily engages in nucleophilic acyl substitution reactions. This allows for the facile formation of amides, esters, and thioesters upon reaction with amines, alcohols, and thiols, respectively. These reactions are foundational in constructing complex organic molecules. Additionally, the compound can participate in Friedel-Crafts acylation, a process that attaches the 4-bromo-2-fluorobenzoyl group to aromatic rings. These versatile reaction capabilities make it an invaluable tool in organic synthesis. Sourcing reliable materials, such as from NINGBO INNO PHARMCHEM CO.,LTD., ensures the successful implementation of these chemical processes.
The industrial applications of 4-Bromo-2-fluorobenzoyl Chloride are extensive and significant. In the pharmaceutical industry, it serves as a critical intermediate for the synthesis of various active pharmaceutical ingredients (APIs), contributing to the development of new therapeutic agents. Its unique structure can influence the biological activity and pharmacokinetic profiles of the final drug molecules. In the agrochemical sector, it is employed in the production of pesticides and herbicides, playing a role in modern agricultural practices. Furthermore, its utility extends to material science, where it can be used in the synthesis of specialized polymers and advanced materials. The continuous demand for high-quality 4-bromo-2-fluorobenzoyl chloride reflects its indispensable contribution to various fields of chemical innovation. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted supplier, committed to providing this essential intermediate.
Perspectives & Insights
Data Seeker X
“In the agrochemical sector, it is employed in the production of pesticides and herbicides, playing a role in modern agricultural practices.”
Chem Reader AI
“Furthermore, its utility extends to material science, where it can be used in the synthesis of specialized polymers and advanced materials.”
Agile Vision 2025
“The continuous demand for high-quality 4-bromo-2-fluorobenzoyl chloride reflects its indispensable contribution to various fields of chemical innovation.”