For anyone working with chemicals, understanding their fundamental properties and associated safety measures is paramount. 2-Hexylthiophene, identified by its CAS number 18794-77-9, is a widely used organic compound with a distinct set of characteristics that dictate its applications and handling protocols. This article aims to provide a detailed overview of its physical and chemical properties, along with crucial safety guidelines for its effective and secure use.

Chemically, 2-Hexylthiophene is a substituted thiophene, a five-membered heterocyclic aromatic ring containing one sulfur atom. Its molecular formula is C10H16S, and it has a molecular weight of 168.30 g/mol. Physically, it is described as a light yellow liquid, though some sources may refer to it as a white crystal, often dependent on purity and temperature. Its melting point is recorded around -39.15°C (estimated), and it has a boiling point typically between 228-230°C. The flash point, which indicates the lowest temperature at which its vapors can ignite, is around 107°C. These properties are critical for determining appropriate storage conditions and operational parameters during synthesis or formulation.

The compound’s density is approximately 0.935 g/cm³, and its refractive index is around 1.4960. Its solubility profile indicates it is soluble in most organic solvents and ethanol but insoluble in water, a common characteristic for many organic molecules with hydrocarbon chains. This insolubility in water is an important consideration when designing reaction work-ups or considering environmental impact.

Regarding safety, 2-Hexylthiophene is classified as potentially harmful. Primary hazards identified include being harmful if swallowed and causing irritation to skin and eyes. Standard precautions for handling such chemicals are therefore essential. This includes wearing appropriate personal protective equipment (PPE) such as gloves and eye protection (safety glasses or goggles). Good laboratory practices, including working in a well-ventilated area or under a fume hood, are strongly recommended to minimize exposure to vapors.

In case of accidental contact, immediate rinsing of affected areas with plenty of water is advised, followed by seeking medical attention if irritation persists. It’s also important to avoid ingestion and contact with skin and eyes during all stages of handling, from receiving the chemical to its use and disposal. Manufacturers often provide detailed Safety Data Sheets (SDS) which offer comprehensive information on hazards, first aid measures, fire-fighting procedures, and spill response, which should always be consulted prior to use.

By understanding and respecting these properties and safety considerations, chemists and technicians can effectively utilize 2-Hexylthiophene in their diverse applications, from creating advanced materials to synthesizing vital pharmaceutical intermediates, ensuring both efficiency and safety in their operations.