The chemical industry thrives on the precise control of reactivity to synthesize novel compounds and materials. Among the arsenal of reagents available to chemists, organolithium compounds hold a special place due to their potent nucleophilic character and versatility. Lithium,[(trimethylsilyl)methyl]- (CAS 1822-00-0), also known by synonyms like lithiomethyltrimethylsilane, exemplifies this. Understanding its chemical properties is key for any professional involved in chemical procurement or synthesis.

At its core, Lithium,[(trimethylsilyl)methyl]- is characterized by the highly polarized lithium-carbon bond, making the carbanionic center exceptionally reactive. This reactivity is strategically harnessed in several key synthetic transformations. As mentioned, its participation in the Peterson Alkenation is significant, where it reacts with carbonyl compounds to generate silyl enol ethers, which can then be further manipulated, often leading to alkenes.

The presence of the trimethylsilyl group is not merely incidental; it plays a crucial role in stabilizing the carbanion. This stabilization influences the regioselectivity and stereoselectivity of reactions, allowing chemists to achieve desired outcomes with greater precision. This makes it an invaluable tool for those looking to buy reagents for complex organic synthesis, especially when specific stereochemical configurations are required.

Furthermore, this compound can react with various electrophiles, including carboxylic acid derivatives, to yield α-silyl ketones. It also serves as a precursor for the synthesis of allylsilanes, which are highly useful in conjugate additions and other C-C bond forming reactions. For researchers and industrial chemists, sourcing this reagent from a dependable manufacturer ensures access to a predictable and potent chemical tool.

When considering the purchase of Lithium,[(trimethylsilyl)methyl]-, it is vital to consult its Material Safety Data Sheet (MSDS) due to its reactive nature. Key physical properties, such as its clear light yellow liquid appearance and its flash point of -49 °C, are important considerations for safe handling and storage. For those seeking to procure this reagent, comparing prices from reputable suppliers and understanding their service offerings, including any technical support, will facilitate informed purchasing decisions.