Lysine, with its reactive side-chain amino group, plays a pivotal role in peptide structure and function. However, in peptide synthesis, its side chain often requires protection to prevent unwanted reactions. While several protecting groups exist, the Alloc group, as seen in Fmoc-Lys(Alloc)-OH, offers a unique strategic advantage.

The use of Fmoc-Lys(Alloc)-OH in peptide synthesis allows for a sophisticated level of control over the lysine side chain. The Alloc group provides orthogonality to the standard Fmoc strategy. This means that after the peptide backbone is assembled using Fmoc chemistry, the Alloc group can be selectively removed. This selective deprotection is typically performed using mild palladium-catalyzed conditions. This process is crucial for various downstream applications, including site-specific conjugation, bioconjugation, or the creation of cyclic peptides where the lysine side chain participates in ring formation.

For researchers looking to buy Fmoc-Lys(Alloc)-OH, sourcing from a trusted manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. is vital. The purity and quality of the reagent directly impact the success of the synthesis. When considering the price of Fmoc-Lys(Alloc)-OH, it is essential to balance cost with the guaranteed quality and reliable supply that experienced suppliers provide. The strategic advantage of using Alloc protection on lysine in complex peptide synthesis cannot be overstated, enabling researchers to achieve results that would be difficult or impossible with less versatile protecting groups.