The precise modification of peptides is crucial for developing targeted therapies, diagnostic tools, and advanced biochemical probes. Fmoc-Lys(Alloc)-OH offers a sophisticated solution for introducing modifications specifically at the lysine side chain during peptide synthesis. This article delves into the advantages of using this reagent and how to source it effectively.

Fmoc-Lys(Alloc)-OH is a derivative of lysine designed for use in Fmoc solid-phase peptide synthesis (SPPS). Its primary utility stems from the orthogonal protection strategy afforded by the Alloc group on the epsilon-amino position. This allows for the selective removal of the Alloc group using palladium catalysis, typically under mild conditions. This selective deprotection is a powerful tool for site-specific functionalization. For example, after the peptide is synthesized, the Alloc group can be removed to attach fluorescent tags, cytotoxic drugs, polyethylene glycol (PEG) chains for improved pharmacokinetics, or to facilitate cyclization reactions.

The choice of a reliable supplier for Fmoc-Lys(Alloc)-OH is critical for ensuring the success of complex peptide synthesis projects. NINGBO INNO PHARMCHEM CO.,LTD. stands as a trusted manufacturer and supplier, providing high-purity Fmoc-Lys(Alloc)-OH. When considering the purchase of this reagent, the price of Fmoc-Lys(Alloc)-OH should be evaluated in conjunction with the supplier's quality assurance and technical support. By utilizing this versatile building block, researchers can achieve precise peptide modifications, pushing the boundaries of peptide-based innovation.