The synthesis of peptides is a cornerstone of modern biotechnology and pharmaceutical research. The efficiency and success of this process hinge on the quality of the reagents used, particularly coupling agents. Among these, 1,3-Diisopropylcarbodiimide (DIC), a carbodiimide compound, has gained significant recognition for its efficacy and practical advantages, especially in solid-phase peptide synthesis (SPPS).

DIC (CAS 693-13-0) serves as an excellent activating agent for carboxylic acids, facilitating the formation of peptide bonds when reacted with amino groups. Its primary appeal in SPPS lies in its physical form. Unlike the widely used but often problematic N,N'-Dicyclohexylcarbodiimide (DCC), DIC is a liquid. This liquid state translates into superior handling characteristics, allowing for precise measurement and addition to reaction mixtures. Furthermore, the urea byproduct generated by DIC is soluble in common organic solvents used in SPPS, such as dichloromethane (DCM) or dimethylformamide (DMF). This solubility is critical, as insoluble byproducts from DCC can clog solid supports and complicate purification, especially in large-scale syntheses.

When considering purchasing DIC, understanding its specifications and the advantages it offers over alternatives is vital. Manufacturers like NINGBO INNO PHARMCHEM offer DIC with a high purity of ≥99.0% (GC), ensuring that the reagent's performance is consistent and reliable. This purity level is essential for minimizing side reactions, such as racemization or the formation of N-acylurea, which can compromise the integrity of the synthesized peptide. By choosing to buy 1,3-Diisopropylcarbodiimide from a trusted supplier, researchers can ensure the quality of their peptide products.

The procurement strategy for DIC should focus on securing a supplier that not only provides high-purity material but also offers competitive pricing and consistent availability. For companies looking to buy DIC, partnering with a manufacturer in China, such as NINGBO INNO PHARMCHEM, can be highly advantageous. We are dedicated to being a reliable supplier, ensuring that your peptide synthesis projects are supported with the necessary high-quality reagents without interruption. Our commitment extends to providing flexible packaging options to meet diverse project scales.

In summary, 1,3-Diisopropylcarbodiimide is an advanced coupling reagent that offers significant benefits for peptide synthesis, particularly its liquid form and soluble byproduct. By understanding these advantages and strategizing your procurement from reputable manufacturers like NINGBO INNO PHARMCHEM, you can enhance the efficiency and success of your peptide synthesis endeavors. We invite you to explore our offerings and experience the quality and service that make us a leading supplier in the chemical industry.