Mastering Peptide Synthesis with Fmoc-Lys(Alloc)-OH: A Guide for Researchers
Fmoc-Lys(Alloc)-OH, also known as N-alpha-Fmoc-N-epsilon-allyloxycarbonyl-L-lysine, is a derivative of the amino acid lysine. Its significance lies in the orthogonal protection strategy it employs. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the alpha-amino group, a standard in Fmoc solid-phase peptide synthesis (SPPS). The key feature, however, is the Alloc (allyloxycarbonyl) group protecting the epsilon-amino group of lysine. This Alloc group offers a distinct advantage: it can be selectively removed under conditions that leave other common protecting groups, such as t-butyl or Boc, intact.
The selective deprotection of the Alloc group is typically achieved using palladium(0) catalysts, often in the presence of a proton source like acetic acid. This orthogonal deprotection capability is invaluable when researchers need to introduce specific modifications at the lysine side chain or construct complex peptide architectures, such as branched peptides or cyclic peptides. For instance, after the peptide chain is assembled, the Alloc group can be removed, allowing for conjugation with other molecules, labeling, or cyclization reactions.
The ability to purchase Fmoc-Lys(Alloc)-OH from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that researchers have access to high-purity materials necessary for successful peptide synthesis. Whether you are looking to buy Fmoc-Lys(Alloc)-OH for custom peptide synthesis or bulk orders, understanding its chemical properties and applications is paramount. The price of Fmoc-Lys(Alloc)-OH can vary based on purity and quantity, making it important to source from reputable manufacturers. Leveraging this reagent can significantly enhance the efficiency and complexity of your peptide research.
Perspectives & Insights
Molecule Vision 7
“The selective deprotection of the Alloc group is typically achieved using palladium(0) catalysts, often in the presence of a proton source like acetic acid.”
Alpha Origin 24
“This orthogonal deprotection capability is invaluable when researchers need to introduce specific modifications at the lysine side chain or construct complex peptide architectures, such as branched peptides or cyclic peptides.”
Future Analyst X
“For instance, after the peptide chain is assembled, the Alloc group can be removed, allowing for conjugation with other molecules, labeling, or cyclization reactions.”