In the realm of Solid-Phase Peptide Synthesis (SPPS), the selection of an appropriate solid support or resin is a critical decision that profoundly impacts the efficiency, purity, and overall success of a peptide synthesis campaign. Among the most widely utilized resins, 2-Chlorotrityl Chloride (2-CTC) Resin, Wang Resin, and Rink Amide Resin each possess distinct characteristics. Understanding these differences, particularly the advantages offered by 2-CTC Resin, is essential for chemists aiming for optimal results. As a prominent supplier, we aim to clarify these distinctions to help you make informed purchasing decisions.

2-Chlorotrityl Chloride Resin (CAS 42074-68-0) is primarily known for its acid-labile linker that allows for cleavage under very mild acidic conditions, typically 1-5% TFA in DCM. This gentleness is a significant advantage when synthesizing peptides that incorporate acid-sensitive amino acid side-chain protecting groups (e.g., Boc, tBu) or those that might degrade under stronger acidic treatments. The steric bulk of the trityl group also helps suppress side reactions like diketopiperazine formation, making it ideal for peptides with C-terminal proline. This makes 2-CTC Resin a go-to choice for producing protected peptide fragments for convergent synthesis or for synthesizing peptides with fragile moieties. If you are looking to buy 2-Chlorotrityl Chloride Resin, prioritizing its mild cleavage capability is often a key driver.

Wang Resin, another commonly used acid-labile resin, requires considerably harsher cleavage conditions, typically 50-95% TFA, to cleave the peptide from the support. While effective for many applications, these stronger conditions can lead to the undesired cleavage or modification of acid-labile side-chain protecting groups. Therefore, Wang Resin is often more suitable for simpler peptides or when the final product is intended to be fully deprotected, and the risk of side-chain modification is less of a concern. Compared to Wang Resin, the milder cleavage afforded by 2-CTC Resin offers superior protection for sensitive molecules.

Rink Amide Resin, on the other hand, is designed for the synthesis of C-terminal amide peptides, which are prevalent in many biologically active peptides. It is also acid-labile but functions by cleaving a linker that results in a free C-terminal amide. While invaluable for producing amide-terminated peptides, it does not directly serve the purpose of synthesizing acid-terminated peptides or protected fragments where the trityl linker is preferred. Thus, the choice between 2-CTC Resin and Rink Amide Resin often depends on the desired C-terminus of the target peptide.

When you consider purchasing 2-Chlorotrityl Chloride Resin, you are opting for a resin that provides a balance of stability during synthesis and facile cleavage under mild conditions. This makes it a highly versatile support for a wide range of SPPS applications, especially when dealing with complex or sensitive peptide sequences. As a leading manufacturer and supplier, we ensure our 2-CTC Resin meets stringent quality standards, offering a reliable and cost-effective solution for your peptide synthesis needs. Compare the benefits and make an informed choice for your next project.