2-Chlorotrityl Chloride Resin: A Key Acid-Labile Support for Efficient Peptide Synthesis
Discover the unparalleled advantages of 2-Chlorotrityl Chloride (2-CTC) Resin, a leading solid support for advanced solid-phase peptide synthesis (SPPS) and organic chemistry. As a premier manufacturer and supplier in China, we offer this high-quality resin essential for creating complex peptides and molecules under mild, controlled conditions. Explore its unique properties and learn how it can elevate your research and development. Get your quote and sample today!
Get a Quote & SampleUnlocking Precision in Peptide Synthesis with 2-CTC Resin
2-Chlorotrityl Chloride Resin
As a trusted 2-Chlorotrityl Chloride Resin supplier, we provide a critical component for your peptide synthesis needs. This resin is renowned for its acid-labile nature, enabling gentle cleavage of synthesized peptides from the solid support. This characteristic is vital for preserving sensitive functional groups in your target molecules, a key advantage that sets it apart from other resins. We offer competitive pricing and reliable supply, making us your go-to manufacturer in China.
- High Purity 2-Chlorotrityl Chloride Resin for SPPS: Essential for the efficient synthesis of peptides with C-terminal proline or cysteine, minimizing side reactions.
- Mild Acidic Cleavage Conditions: Facilitates the removal of peptides using low concentrations of TFA, preserving acid-sensitive protecting groups.
- Versatile Application in Organic Synthesis: Beyond peptide synthesis, this resin is valuable for preparing various small organic molecules and combinatorial libraries.
- Reliable Manufacturer & Supplier in China: Benefit from consistent quality and bulk availability, ensuring your research projects proceed without interruption.
Key Advantages of Utilizing 2-CTC Resin
Superior Lability under Mild Conditions
The 2-chloro substitution on the trityl group significantly enhances its lability to mild acidic cleavage. This means you can confidently cleave your synthesized peptide using as little as 1-5% TFA in DCM, a stark contrast to harsher conditions required by other resins. This feature is crucial when buy 2-Chlorotrityl Chloride Resin for applications involving acid-sensitive protecting groups.
Reduced Side Reactions and Enhanced Purity
The steric bulk of the trityl group inherent in 2-Chlorotrityl Chloride Resin helps suppress side reactions like diketopiperazine (DKP) formation, especially critical for C-terminal proline residues. This improved control contributes to higher yields and purer final products, making it a preferred choice for demanding peptide synthesis projects.
Broad Compatibility and High Loading Capacity
2-CTC Resin is compatible with a wide range of synthetic methodologies, including Fmoc/tBu strategy for SPPS, and is instrumental in the synthesis of oligonucleotides and diverse small organic molecules. Its good loading capacity ensures efficient attachment of the first building block, a vital factor for overall synthesis success when you purchase this resin.
Diverse Applications for 2-Chlorotrityl Chloride Resin
Solid-Phase Peptide Synthesis (SPPS)
As a leading supplier of SPPS resins, we offer 2-Chlorotrityl Chloride Resin ideal for Fmoc-based synthesis. Its mild cleavage conditions make it perfect for preparing protected peptide fragments, crucial for convergent peptide synthesis strategies. Buy 2-Chlorotrityl Chloride Resin for precise peptide assembly.
Organic Synthesis
The versatility of 2-CTC resin extends to the solid-phase synthesis of various small organic molecules. It provides a convenient handle for building complex structures, simplifying purification steps. Explore purchasing options from our China-based manufacturing facility.
Combinatorial Chemistry & Drug Discovery
For researchers in drug discovery, 2-Chlorotrityl Chloride Resin is an excellent choice for generating diverse compound libraries. Its ease of cleavage under mild conditions supports efficient solid-phase combinatorial chemistry, enabling rapid screening of potential drug candidates.
Custom Peptide Manufacturing
When seeking a reliable manufacturer for custom peptide synthesis, our 2-Chlorotrityl Chloride Resin is a foundational element. It supports the synthesis of complex peptides with high fidelity, meeting stringent quality requirements for pharmaceutical and research applications.