Sourcing Fmoc-Val-OSu (CAS 130878-68-1): A Guide for Peptide Chemists
Peptide synthesis is a cornerstone of modern biochemical and pharmaceutical research, and the availability of high-quality reagents is crucial for success. Fmoc-Val-OSu, identified by CAS number 130878-68-1, is a vital amino acid derivative that facilitates efficient peptide chain elongation. For many researchers, the decision to buy Fmoc-Val-OSu involves careful consideration of purity, reactivity, and supplier reliability, with China emerging as a significant source for this compound.
Fmoc-Val-OSu, a derivative of valine, is protected with the Fmoc (9-fluorenylmethyloxycarbonyl) group. This protecting group is widely favored in solid-phase peptide synthesis (SPPS) due to its facile removal under mild basic conditions, which is orthogonal to most side-chain protecting groups used in peptide chemistry. This orthogonality is key to building complex peptide structures without compromising sensitive functional groups. The N-hydroxysuccinimide (NHS) ester functionality of Fmoc-Val-OSu enhances the reactivity of the valine carboxyl group, enabling efficient coupling reactions with the amine group of the peptide resin.
When procuring Fmoc-Val-OSu, purity is a paramount concern. Researchers typically demand a purity of 99% or higher, often confirmed by HPLC analysis. High-purity Fmoc-Val-OSu ensures that the resulting peptides are free from contaminants, which is critical for accurate experimental outcomes, particularly in sensitive applications like drug development or detailed proteomic studies. Many Chinese manufacturers and suppliers offer Fmoc-Val-OSu with documented purity, often accompanied by a Certificate of Analysis (CoA). It is always advisable to obtain and review the CoA before making a purchase.
The chemical formula for Fmoc-Val-OSu is C24H24N2O6, with a molecular weight of approximately 436.45 g/mol. These identifiers are essential for accurate inventory management and for performing precise calculations during the synthesis process. For those looking to buy Fmoc-Val-OSu in bulk or for cost-effective sourcing, Chinese suppliers often provide competitive pricing, making them an attractive option for laboratories worldwide.
In summary, Fmoc-Val-OSu is an essential reagent for any laboratory engaged in peptide synthesis. Its high purity, efficient coupling mechanism, and the advantages of the Fmoc protection strategy make it an indispensable tool. By understanding the importance of quality and working with reliable suppliers, researchers can ensure the success of their peptide synthesis projects.
Fmoc-Val-OSu, a derivative of valine, is protected with the Fmoc (9-fluorenylmethyloxycarbonyl) group. This protecting group is widely favored in solid-phase peptide synthesis (SPPS) due to its facile removal under mild basic conditions, which is orthogonal to most side-chain protecting groups used in peptide chemistry. This orthogonality is key to building complex peptide structures without compromising sensitive functional groups. The N-hydroxysuccinimide (NHS) ester functionality of Fmoc-Val-OSu enhances the reactivity of the valine carboxyl group, enabling efficient coupling reactions with the amine group of the peptide resin.
When procuring Fmoc-Val-OSu, purity is a paramount concern. Researchers typically demand a purity of 99% or higher, often confirmed by HPLC analysis. High-purity Fmoc-Val-OSu ensures that the resulting peptides are free from contaminants, which is critical for accurate experimental outcomes, particularly in sensitive applications like drug development or detailed proteomic studies. Many Chinese manufacturers and suppliers offer Fmoc-Val-OSu with documented purity, often accompanied by a Certificate of Analysis (CoA). It is always advisable to obtain and review the CoA before making a purchase.
The chemical formula for Fmoc-Val-OSu is C24H24N2O6, with a molecular weight of approximately 436.45 g/mol. These identifiers are essential for accurate inventory management and for performing precise calculations during the synthesis process. For those looking to buy Fmoc-Val-OSu in bulk or for cost-effective sourcing, Chinese suppliers often provide competitive pricing, making them an attractive option for laboratories worldwide.
In summary, Fmoc-Val-OSu is an essential reagent for any laboratory engaged in peptide synthesis. Its high purity, efficient coupling mechanism, and the advantages of the Fmoc protection strategy make it an indispensable tool. By understanding the importance of quality and working with reliable suppliers, researchers can ensure the success of their peptide synthesis projects.
Perspectives & Insights
Molecule Vision 7
“By understanding the importance of quality and working with reliable suppliers, researchers can ensure the success of their peptide synthesis projects.”
Alpha Origin 24
“Peptide synthesis is a cornerstone of modern biochemical and pharmaceutical research, and the availability of high-quality reagents is crucial for success.”
Future Analyst X
“Fmoc-Val-OSu, identified by CAS number 130878-68-1, is a vital amino acid derivative that facilitates efficient peptide chain elongation.”