Organic synthesis is the backbone of numerous industries, from pharmaceuticals and agrochemicals to materials science. Central to this field is the availability of versatile and reactive chemical intermediates. 3-Chloropivaloyl chloride (CAS: 4300-97-4) is one such compound, highly valued for its utility as an acylation agent and its role in cyclization reactions. For chemists and procurement managers, understanding its chemistry and where to buy it reliably is key.

Understanding the Chemical Nature of 3-Chloropivaloyl Chloride

3-Chloropivaloyl chloride, also known by its IUPAC name 3-chloro-2,2-dimethylpropanoyl chloride, is an acid chloride. Its molecular formula is C5H8Cl2O, and it possesses a molecular weight of 155.02. Typically, it appears as a colorless to light yellow transparent liquid with a purity assay of ≥98.0%. This purity level is critical for ensuring predictable outcomes in sensitive organic reactions. Its physical properties, such as a boiling point around 85-86 °C at 60 mm Hg and a density of approximately 1.199 g/mL at 25 °C, are important considerations for handling and process design.

Key Applications in Organic Synthesis

The reactivity of the acid chloride group in 3-Chloropivaloyl chloride makes it a potent reagent for introducing the 3-chloro-2,2-dimethylpropanoyl group into other molecules. Its primary recognized applications include:

  • Intermediate for Agrochemicals: It is a crucial precursor in the synthesis of herbicides like Clomazone and Oxadiazon, contributing to the development of modern crop protection solutions.
  • Intermediate for Pharmaceuticals: While less emphasized than its agrochemical role, its chemical structure and reactivity make it a valuable building block for various pharmaceutical syntheses.
  • Acylation Reactions: It serves as an effective acylating agent, reacting with nucleophiles like alcohols and amines to form esters and amides, respectively.
  • Cyclization Reactions: It plays a role in isoxazolone cyclizations, a specific type of organic reaction.
  • Potential Material Science Applications: Some sources suggest its use as a raw material for rubber additives and photographic photosensitive materials, indicating broader industrial potential.

Procuring 3-Chloropivaloyl Chloride: What to Look For

When looking to purchase 3-Chloropivaloyl chloride, discerning buyers focus on several aspects:

  • Supplier Reputation: Partner with established chemical manufacturers and suppliers known for quality and reliability.
  • Product Specifications: Verify the purity (assay) and ensure it meets your specific reaction requirements.
  • Pricing and Availability: Obtain competitive quotes for bulk quantities and confirm lead times for delivery.
  • Safety Information: Always review the Material Safety Data Sheet (MSDS) for proper handling and safety precautions.

NINGBO INNO PHARMCHEM CO.,LTD. is a trusted source for high-quality 3-Chloropivaloyl chloride, catering to the needs of organic chemists and manufacturers worldwide. We offer this essential intermediate with a commitment to purity and reliability. Contact us today to inquire about the price and availability of 3-Chloropivaloyl chloride for your next synthesis project and experience the advantage of working with a dedicated supplier.