The pharmaceutical industry is continuously seeking high-purity chemical intermediates to drive the synthesis of novel and life-saving drugs. Among the essential building blocks utilized in this sector is 3-Chloropivaloyl chloride (CAS: 4300-97-4). This versatile organic compound, known for its role as an acylation reagent and cyclization agent, is indispensable for creating complex pharmaceutical molecules. For researchers and manufacturers, understanding its applications and securing a reliable supply chain is crucial.

The Significance of 3-Chloropivaloyl Chloride in Pharma

3-Chloropivaloyl chloride, a clear to light yellow transparent liquid, is recognized for its chemical utility in organic synthesis. Its CAS number, 4300-97-4, is synonymous with a compound that facilitates crucial chemical transformations. In pharmaceutical manufacturing, it's employed as an intermediate to construct specific molecular frameworks that form the backbone of many active pharmaceutical ingredients (APIs) and advanced intermediates. While the primary applications highlighted in many sources are agrochemical, its chemical reactivity makes it a valuable tool for synthetic organic chemists in the pharmaceutical realm as well.

Key Properties for Pharmaceutical Applications

When sourcing chemical intermediates for pharmaceutical development, several attributes of 3-Chloropivaloyl chloride are particularly important:

  • High Purity: A minimum assay of ≥98.0% is typically required to ensure the efficiency and selectivity of pharmaceutical synthesis pathways, minimizing the risk of impurities in the final API.
  • Chemical Reactivity: Its effectiveness as an acylation agent allows for the introduction of specific functional groups, a common step in multi-stage drug synthesis.
  • Availability: While R&D quantities are important, the ability to scale up production with a reliable supplier offering bulk packaging (like 200 kg drums) is vital for commercialization.

Sourcing Strategies for Pharmaceutical Companies

Pharmaceutical companies looking to purchase 3-Chloropivaloyl chloride should prioritize suppliers that offer:

  • Quality Compliance: Suppliers who can provide detailed technical data, Certificates of Analysis, and potentially support with regulatory documentation are highly preferred.
  • Consistent Supply: A stable and predictable supply chain is critical for ongoing drug manufacturing.
  • Responsive Customer Service: Access to product information, pricing, and timely delivery is essential for R&D timelines and production schedules.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a premier supplier of high-quality chemical intermediates for the pharmaceutical industry. We understand the rigorous demands placed on pharmaceutical research and manufacturing. Our dedication to quality and reliability makes us an ideal partner for companies seeking 3-Chloropivaloyl chloride for their synthesis needs. Contact us to learn more about our pharmaceutical intermediates and to inquire about pricing and sample availability for your critical projects.