For research and development scientists, the selection of chemical intermediates is a critical step in the innovation process. 1,4-Difluorobenzene (CAS 540-36-3) stands out as a versatile and highly valuable building block in organic synthesis, particularly for creating complex fluorinated compounds. Its unique properties make it indispensable in fields ranging from pharmaceuticals and agrochemicals to cutting-edge materials science. This guide explores the applications and considerations for R&D scientists looking to utilize this essential intermediate.

The Chemical Profile of 1,4-Difluorobenzene

With a molecular formula of C6H4F2 and CAS number 540-36-3, 1,4-Difluorobenzene is characterized by its benzene ring substituted with fluorine atoms at the para positions. This symmetrical structure influences its electronic properties and reactivity. Key physical characteristics include its appearance as a colorless to pale yellow transparent liquid, a boiling point of 88-89°C, and a melting point of -13°C. Its assay purity is typically ≥99.0%, a standard that ensures reliability in sensitive reactions. Understanding these properties is crucial for R&D scientists when designing synthetic routes and experimental conditions.

Applications in Key Scientific Fields

The utility of 1,4-Difluorobenzene spans several scientific disciplines:

  • Pharmaceutical Synthesis: It serves as a vital intermediate in the synthesis of numerous pharmaceutical compounds. The presence of fluorine atoms can significantly alter a drug molecule's metabolic stability, lipophilicity, and binding affinity, making 1,4-Difluorobenzene a sought-after precursor for developing new therapeutic agents. Scientists often search for high purity 1,4-difluorobenzene for these critical drug development pathways.
  • Agrochemicals: In the agrochemical sector, 1,4-Difluorobenzene is used to synthesize effective herbicides, pesticides, and fungicides. Fluorinated agrochemicals often exhibit enhanced efficacy and targeted action, contributing to improved crop yields and protection.
  • Advanced Materials and Liquid Crystals: Its electronic properties make it valuable in materials science, particularly in the development of liquid crystal materials used in displays and organic electronics. Researchers also utilize it as a building block for specialty polymers with unique thermal and chemical resistance.
  • Organic Chemistry Research: As a common substrate, 1,4-Difluorobenzene is employed in various research studies to explore new synthetic methodologies, reaction mechanisms, and the synthesis of novel fluorinated organic compounds.

Sourcing High-Quality 1,4-Difluorobenzene

For R&D scientists, the ability to procure high-quality 1,4-Difluorobenzene with reliable specifications is paramount. Sourcing from reputable manufacturers and suppliers, especially those in China, offers access to both quality and cost-effectiveness. When you inquire about CAS 540-36-3 price for pharma or research applications, look for suppliers who provide detailed product information, including COA and MSDS. These documents are essential for validating the purity and suitability of the compound for your specific research objectives.

Partnering with NINGBO INNO PHARMCHEM CO.,LTD.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of fine chemicals, including 1,4-Difluorobenzene. We are committed to supporting the scientific community by providing high-purity intermediates that meet rigorous standards. Whether you are looking to buy 1,4-difluorobenzene for laboratory synthesis or large-scale R&D projects, we offer reliable sourcing and technical support. Contact us to discuss your requirements and to learn how our high-quality products can advance your research.