In the dynamic landscape of pharmaceutical development and chemical manufacturing, access to high-quality, reliable intermediates is crucial for success. 1-Acetylpiperazine, identified by CAS number 13889-98-0, is a compound that plays a significant role as a versatile pharmaceutical intermediate. Its specific chemical structure and properties make it an essential building block in the synthesis of various active pharmaceutical ingredients (APIs). For R&D scientists and procurement managers, understanding the sourcing of this compound, particularly from reputable manufacturers in China, is a key strategic consideration.

Understanding 1-Acetylpiperazine

1-Acetylpiperazine, with the chemical formula C6H12N2O and a molecular weight of 128.17, is a derivative of piperazine. It is typically characterized by its pale yellow crystalline appearance and a melting point range of 31-34 °C. A crucial specification for its use in pharmaceutical synthesis is its purity, which is often required to be 97% minimum. This high level of purity is essential for ensuring the efficacy and safety of the final drug products, minimizing side reactions, and achieving consistent batch-to-batch quality.

Applications in the Pharmaceutical Industry

The primary function of 1-Acetylpiperazine is as a pivotal intermediate in the synthesis of pharmaceuticals. Its structural features allow it to be readily incorporated into complex organic molecules, serving as a scaffold for drug design. It is utilized in the development of APIs targeting a variety of therapeutic areas, including but not limited to CNS disorders, cardiovascular conditions, and oncology. The ability to efficiently buy 1-Acetylpiperazine from trusted sources directly impacts the speed and cost-effectiveness of drug development pipelines. Pharmaceutical companies often look for suppliers who can guarantee:

  • Consistent High Purity: Meeting the 97% min specification for reliable synthesis.
  • Stable Supply: Ensuring availability for ongoing production needs.
  • Competitive Pricing: Access to cost-effective materials without compromising quality.
  • Regulatory Compliance and Documentation: Providing necessary certificates and data for regulatory submissions.

Sourcing from China: Advantages and Considerations

China has established itself as a leading global supplier of chemical intermediates. When you aim to purchase 1-Acetylpiperazine from this region, it's beneficial to partner with established and reputable manufacturers. These companies often possess large-scale production capabilities, advanced quality control systems, and competitive pricing structures. Key aspects to evaluate when selecting a Chinese supplier include their manufacturing capacity, R&D support, and their experience in serving the international pharmaceutical market. Understanding the total cost, including shipping and import duties, is also vital when comparing price quotes.

Conclusion

1-Acetylpiperazine (CAS 13889-98-0) is a fundamental intermediate that underpins much of modern pharmaceutical innovation. By understanding its properties and diligently selecting a reliable Chinese manufacturer or supplier, companies can secure a consistent supply of this critical compound, thereby facilitating efficient and cost-effective drug development and manufacturing processes. The pursuit of high-purity intermediates like 1-Acetylpiperazine remains a cornerstone of pharmaceutical excellence.