The pharmaceutical industry is in constant pursuit of novel drug candidates, and the foundation of this innovation lies in the availability of high-quality chemical intermediates. 1-Boc-3-Hydroxypyrrolidine (CAS: 103057-44-9) has emerged as a cornerstone building block for many advanced pharmaceutical synthesis projects. Its unique structural features, including the Boc-protected amine and the hydroxyl group on a pyrrolidine ring, make it exceptionally versatile for creating complex molecular architectures central to modern drug development.

Understanding 1-Boc-3-Hydroxypyrrolidine

Chemically known as tert-Butyl 3-hydroxypyrrolidine-1-carboxylate, this compound (C9H17NO3, MW: 187.24 g/mol) typically appears as a white powder. Its well-defined physical properties, such as a melting point around 62.1-62.2°C, are critical for its handling and incorporation into synthetic schemes. The Boc group provides a stable, yet easily removable, protection for the pyrrolidine nitrogen, allowing selective reactions to occur at the hydroxyl functional group or elsewhere in a more complex molecule. This makes it an indispensable intermediate for researchers aiming to buy and utilize it in their synthesis strategies.

Applications in Pharmaceutical R&D

The demand for 1-Boc-3-Hydroxypyrrolidine is high across various pharmaceutical research areas. It serves as a key precursor in the synthesis of:

  • Chiral Drugs: Its inherent chirality makes it suitable for synthesizing enantiomerically pure drug candidates, essential for efficacy and safety.
  • Peptidomimetics: It can be incorporated into structures that mimic peptides, often with improved stability and bioavailability.
  • Enzyme Inhibitors: Many research programs focused on developing inhibitors for targets like kinases or proteases utilize this pyrrolidine derivative.
  • Other APIs: Its versatile structure allows it to be integrated into a broad spectrum of Active Pharmaceutical Ingredients.

NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer and supplier of pharmaceutical intermediates in China, is dedicated to providing researchers and companies with this crucial chemical. By ensuring high purity (typically 97% min) and reliable supply, we empower advancements in drug discovery.

Procurement Advice for Buyers

When seeking to buy 1-Boc-3-Hydroxypyrrolidine, it is advisable to partner with manufacturers who demonstrate a strong commitment to quality control and traceability. Requesting Certificates of Analysis (CoA) for each batch is standard practice. Understanding the supplier's capacity, lead times, and commitment to customer service will ensure a smooth procurement process. For your pharmaceutical R&D needs, consider sourcing your 1-Boc-3-Hydroxypyrrolidine from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD. to guarantee the quality and consistency your projects demand.