In the intricate world of pharmaceutical synthesis, the selection of appropriate building blocks is fundamental to achieving desired molecular structures and therapeutic outcomes. 1-Boc-3-Hydroxypyrrolidine (CAS: 103057-44-9) stands out as a highly valuable and versatile intermediate, instrumental in the synthesis of numerous complex organic compounds, particularly those with potential pharmaceutical applications. As a leading chemical manufacturer, understanding its properties and applications is crucial for researchers and product development teams.

Chemical Profile and Properties

1-Boc-3-Hydroxypyrrolidine is characterized by its chemical formula C9H17NO3 and a molecular weight of 187.24 g/mol. It typically presents as a white to off-white powder, with a melting point range of 62.1-62.2°C. The presence of the tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom and a hydroxyl group at the 3-position of the pyrrolidine ring grants it unique reactivity. This bifunctional nature allows for selective chemical transformations, making it an ideal starting material for chemists aiming to construct sophisticated molecular architectures.

Synthetic Utility in Drug Development

The primary utility of 1-Boc-3-Hydroxypyrrolidine lies in its role as a chiral building block. It is frequently employed in the synthesis of pharmaceuticals targeting a wide array of medical conditions. For instance, it serves as a key intermediate in the preparation of compounds that inhibit specific enzymes, modulate receptor activity, or act as antiviral agents. Researchers often purchase this compound to explore new chemical entities (NCEs) with improved pharmacokinetic profiles and reduced side effects. The demand for high-purity 1-Boc-3-Hydroxypyrrolidine from reliable manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., is driven by its consistent performance in these critical synthetic routes.

Sourcing Strategies for Researchers and Manufacturers

For research scientists and pharmaceutical manufacturers, the ability to buy 1-Boc-3-Hydroxypyrrolidine reliably and cost-effectively is a significant advantage. Working with established chemical suppliers who can guarantee high purity (e.g., 97% min) and consistent batch-to-batch quality is paramount. Factors such as secure packaging, clear CAS number (103057-44-9), and readily available technical data (like CoAs) streamline the procurement process. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being that trusted supplier, providing the necessary chemical building blocks to accelerate your drug discovery and development pipelines.

The strategic use of intermediates like 1-Boc-3-Hydroxypyrrolidine is a hallmark of efficient and innovative pharmaceutical development. By understanding its chemical profile and synthetic potential, and by partnering with dependable manufacturers, R&D teams can effectively translate laboratory discoveries into life-changing medicines.