In the quest for novel therapeutics, the availability of high-quality, versatile chemical building blocks is indispensable. 1-Boc-piperidine-4-carboxaldehyde, identified by its CAS number 137076-22-3, is one such critical intermediate that empowers medicinal chemists and pharmaceutical developers. This article explores the properties, applications, and strategic sourcing of this vital compound for B2B professionals.

Understanding 1-Boc-piperidine-4-carboxaldehyde

1-Boc-piperidine-4-carboxaldehyde is a white crystalline powder with a molecular formula of C11H19NO3 and a molecular weight of 213.28 g/mol. Its defining characteristic is the presence of a piperidine ring functionalized with a Boc-protected nitrogen and an aldehyde group at the 4-position. This unique structure makes it an exceptionally useful synthon in organic chemistry, particularly in the construction of complex nitrogen-containing heterocycles commonly found in pharmaceutical agents. The typical purity offered by manufacturers is 97% or higher, ensuring reliable performance in sensitive synthetic routes.

Applications Driving Pharmaceutical Innovation

The versatility of 1-Boc-piperidine-4-carboxaldehyde is evident in its broad spectrum of applications within drug development:

  • Synthesis of Kinase Inhibitors: It serves as a key intermediate in the production of Pim-1 inhibitors, a class of compounds targeted for their potential in cancer treatment.
  • Diabetes Therapeutics: The compound is utilized in the synthesis of selective GPR119 agonists, which are investigated as potential treatments for type II diabetes by modulating glucose homeostasis.
  • Antiviral Agents: It plays a role in creating inhibitors of M-tropic (R5) HIV-1 replication, contributing to the development of new antiviral therapies.
  • Central Nervous System Drugs: The synthesis of selective 5-HT6 antagonists, explored for treating cognitive disorders like Alzheimer's disease and schizophrenia, also relies on this intermediate.
  • Methodology Advancement: Beyond specific drug targets, it is used in research to develop and refine synthetic methodologies, such as vinylogous Mannich reactions, thereby expanding the toolkit of synthetic chemists.

Strategic Sourcing for B2B Clients

For B2B customers, securing a consistent and cost-effective supply of 1-Boc-piperidine-4-carboxaldehyde is critical. Key considerations when sourcing this intermediate include:

  • Supplier Selection: It is imperative to partner with reputable manufacturers and suppliers who guarantee product quality, offer competitive pricing, and provide reliable delivery. China-based suppliers are often a primary source due to production capacity and cost efficiencies.
  • Quality Verification: Always request a Certificate of Analysis (CoA) to confirm purity and specifications. This document is vital for ensuring the suitability of the material for pharmaceutical applications.
  • Pricing and Negotiation: Engage with multiple suppliers to compare pricing for CAS 137076-22-3. Bulk order discounts and long-term supply agreements can significantly optimize procurement costs.
  • Technical and Logistical Support: Ensure your supplier can offer technical assistance and has efficient logistical capabilities for international delivery. Understanding lead times and customs requirements is also important.

Conclusion: Empowering Your Drug Development Pipeline

1-Boc-piperidine-4-carboxaldehyde is a foundational component in the modern pharmaceutical development landscape. By leveraging the capabilities of reliable manufacturers and understanding the nuances of B2B chemical procurement, researchers and companies can ensure they have a steady supply of this essential building block. We are dedicated to serving the pharmaceutical industry with high-quality chemical intermediates like 1-Boc-piperidine-4-carboxaldehyde, empowering your innovation from discovery to market.